Evidence map›Paper›PMID 31239331›Full record

Observational studyJournal of neurointerventional surgery2019

Mechanical thrombectomy for basilar artery occlusion: efficacy, outcomes, and futile recanalization in comparison with the anterior circulation.

Thomas Raphael Meinel, Johannes Kaesmacher, Panagiotis Chaloulos-Iakovidis, Leonidas Panos, Pasquale Mordasini, Pascal J Mosimann, Patrik Michel, Steven Hajdu, Marc Ribo, Manuel Requena and 10 more

Registry-linked trialOpen access · hybridAbstract readComparative StudyMulticenter StudyObservational Study
In one paragraph

Observational study in Journal of neurointerventional surgery, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03496064 (Bernese-European RegistrY for Ischemic Stroke Patients Treated Outside Current Guidelines With Neurothrombectomy Devices Using the SOLITAIRE™ FR With the Intention For Thrombectomy), which is not on this map. Cited by 59 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
59citing papers in PubMed, 6 pooled it
14.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03496064 completednot on this map

Bernese-European RegistrY for Ischemic Stroke Patients Treated Outside Current Guidelines With Neurothrombectomy Devices Using the SOLITAIRE™ FR With the Intention For Thrombectomy

TypeobservationalSponsorInsel Gruppe AG, University Hospital BernRan2017 to 2018Enrolled2,000ConditionsIschemic StrokeArmsSuccessful reperfusion
3 · Its place in the literature

Who cites it

59 citing papers in PubMed, 6 syntheses or guidelines pooled it, 135 citations in OpenAlex.

  1. Mechanical thrombectomy versus medical management for acute basilar artery occlusions: A meta-analysis of randomized trials.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2026
    Pooled it
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  3. Mechanical thrombectomy in anterior vs. posterior circulation stroke: A systematic review and meta-analysis.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2024
    Pooled it
  4. Pooled it
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  12. Observational
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  14. Influencing factors of futile recanalization after endovascular intervention in patients with acute basilar artery occlusion.Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2024
    Article
  15. Article
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  20. Basilar artery occlusion: A review of clinicoradiologic features, treatment selection, and endovascular techniques.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 8 institutions in 7 countries.

Thomas Raphael Meinel *Neurology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.ORCID http://orcid.org/0000-0002-0647-9273
Johannes Kaesmacher *Institute of Diagnostic and Interventional Neuroradiology, Institute of Diagnostic, Interventional and Pediatric Radiology and Department of Neurology, Inselspital, University Hospital Bern, University of Bern, Bern, Switzerland.
Panagiotis Chaloulos-IakovidisNeurology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Leonidas PanosNeurology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Pasquale MordasiniDepartment for Diagnostic and Interventional Neuroradiology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Pascal J MosimannDepartment for Diagnostic and Interventional Neuroradiology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Patrik MichelDepartment of Neurology, CHUV Lausanne, Lausanne, Switzerland.
Steven HajduDepartment of Interventional and Diagnostic Neuroradiology, University Hospital of Lausanne, CHUV, Lausanne, Switzerland.
Marc RiboDepartment of Neurology, Vall d'Hebron University Hospital, Barcelona, Spain.
Manuel RequenaDepartment of Neurology, Vall d'Hebron University Hospital, Barcelona, Spain.
Christian MaegerleinDepartment of Diagnostic and Interventional Neuroradiology, Klinikum rechts der Isar, Technische Universität, Munich, Germany.ORCID http://orcid.org/0000-0003-4885-7671
Benjamin FriedrichDepartment of Diagnostic and Interventional Neuroradiology, Klinikum rechts der Isar, Technische Universität, Munich, Germany.ORCID http://orcid.org/0000-0002-2198-9925
Vincent CostalatDepartment of Neuroradiology, Centre Hospitalier Regional Universitaire de Montpellier, Montpellier, France.
Amel BenaliDepartment of Neuroradiology, Centre Hospitalier Regional Universitaire de Montpellier, Montpellier, France.
Laurent PierotDepartment of Neuroradiology, Centre Hospitalier Universitaire de Reims, Reims, France.ORCID http://orcid.org/0000-0002-6893-661X
Matthias GawlitzaDepartment of Neuroradiology, Centre Hospitalier Universitaire de Reims, Reims, France.
Joanna SchaafsmaNeurology, Toronto Western Hospital, Toronto, Ontario, Canada.
Vitor M PereiraJoint Department of Medical Imaging, Toronto Western Hospital, Toronto, Ontario, Canada.
Jan Gralla *Department for Diagnostic and Interventional Neuroradiology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Urs Fischer *Neurology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
University of Bern · CHCentre Hospitalier Universitaire de Montpellier · FRCentre Hospitalier Universitaire de Reims · FRHebron University · PSToronto Western Hospital · CATUM Klinikum · DEHôpital Orthopédique de la Suisse Romande · CHUniversity Hospital of Lausanne · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPerforming mechanical thrombectomy (MT) in patients with basilar artery occlusion (BAO) is currently not evidence-based.

objectiveTo compare patients' outcome, relative merits of achieving recanalization, and predictors of futile recanalization (FR) between BAO and anterior circulation large vessel occlusion (ACLVO) MT.

methodsIn the multicenter BEYOND-SWIFT registry (NCT03496064), univariate and multivariate (displayed as adjusted Odds Ratios, aOR and 95% confidence intervals, 95%-CI) outcome comparisons between BAO (N=165) and ACLVO (N=1574) were performed. The primary outcome was favorable outcome at 90 days (modified Rankin Scale, mRS 0-2). Secondary outcome included mortality, symptomatic intracranial hemorrhage (sICH) and FR. The relative merits of achieving successful recanalization between ACLVO and BAO were evaluated with interaction terms.

resultsMT in BAO was more often technically effective and equally safe in regards to mortality and sICH when compared to ACLVO. When adjusting for baseline differences, there was no significant difference between BAO vs ACLVO regarding rates of favorable outcome (aOR 0.986, 95%-CI 0.553 - 1.758). However, BAO were associated with increased rates of FR (aOR 2.146, 95%-CI 1.267 - 3.633). Predictors for FR were age, stroke severity, maneuver count and intracranial stenting. No significant heterogeneity on the relative merits of achieving successful recanalization on several outcome parameters were observed when comparing BAO and ACLVO.

conclusionsIn selected patients, similar outcomes can be achieved in BAO and ACLVO patients treated with MT. Randomized controlled trials comparing patient selection and interventional strategies seem warranted to avoid FR. TRIAL REGISTRATION NUMBER: NCT03496064.

Indexed as

AgedAged, 80 and overBasilar ArteryCerebrovascular CirculationCerebrovascular DisordersFemaleFollow-Up StudiesHumansMaleMiddle AgedRegistriesRetrospective StudiesThrombectomyTreatment Outcomeangiographyinterventionstrokethrombectomythrombolysis

Identifiers

PMID31239331
PMCPMC6902072
OpenAlexW2953950059

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.