Evidence map›Paper›PMID 31239312›Full record

ArticleLife science alliance2019

Fibro-adipogenic progenitors of dystrophic mice are insensitive to NOTCH regulation of adipogenesis.

Milica Marinkovic, Claudia Fuoco, Francesca Sacco, Andrea Cerquone Perpetuini, Giulio Giuliani, Elisa Micarelli, Theodora Pavlidou, Lucia Lisa Petrilli, Alessio Reggio, Federica Riccio and 7 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Life science alliance, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.

0numbers the graph read from it
0cells of the map it votes in
56citing papers in PubMed
2.9field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

56 citing papers in PubMed, 64 citations in OpenAlex.

  1. Review
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  11. Intramuscular adipose tissue: from progenitor to pathology.American journal of physiology. Cell physiology · 2025
    Review
  12. Review
  13. Article
  14. Muscle Health & Fatty Infiltration with Advanced Rotator Cuff Pathology.Current reviews in musculoskeletal medicine · 2025
    Review
  15. PdgfrαGenes & diseases · 2025
    Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 2 institutions in 2 countries.

Milica MarinkovicDepartment of Biology, University of Rome Tor Vergata, Rome, Italy.ORCID 0000-0002-5868-9539
Claudia FuocoDepartment of Biology, University of Rome Tor Vergata, Rome, Italy.
Francesca SaccoDepartment of Biology, University of Rome Tor Vergata, Rome, Italy.
Andrea Cerquone PerpetuiniDepartment of Biology, University of Rome Tor Vergata, Rome, Italy.
Giulio GiulianiDepartment of Biology, University of Rome Tor Vergata, Rome, Italy.ORCID 0000-0002-4648-0076
Elisa MicarelliDepartment of Biology, University of Rome Tor Vergata, Rome, Italy.ORCID 0000-0002-1180-0359
Theodora PavlidouDepartment of Biology, University of Rome Tor Vergata, Rome, Italy.
Lucia Lisa PetrilliDepartment of Biology, University of Rome Tor Vergata, Rome, Italy.
Alessio ReggioDepartment of Biology, University of Rome Tor Vergata, Rome, Italy.ORCID 0000-0001-5333-7502
Federica RiccioDepartment of Biology, University of Rome Tor Vergata, Rome, Italy.ORCID 0000-0003-2939-3306
Filomena SpadaDepartment of Biology, University of Rome Tor Vergata, Rome, Italy.
Simone VumbacaDepartment of Biology, University of Rome Tor Vergata, Rome, Italy.ORCID 0000-0003-1940-3355
Alessandro ZuccottiDepartment of Biology, University of Rome Tor Vergata, Rome, Italy.
Luisa CastagnoliDepartment of Biology, University of Rome Tor Vergata, Rome, Italy.
Matthias MannDepartment of Proteomics and Signal Transduction, Max-Planck Institute of Biochemistry, Martinsried, Germany.
Cesare GargioliDepartment of Biology, University of Rome Tor Vergata, Rome, Italy cesare.gargioli@uniroma2.it.
Gianni CesareniDepartment of Biology, University of Rome Tor Vergata, Rome, Italy cesareni@uniroma2.it.ORCID 0000-0002-9528-6018
University of Rome Tor Vergata · ITMax Planck Institute of Biochemistry · DE

Funding

European Research Council 322749
6 · The paper itself

Abstract

Fibro-adipogenic progenitors (FAPs) promote satellite cell differentiation in adult skeletal muscle regeneration. However, in pathological conditions, FAPs are responsible for fibrosis and fatty infiltrations. Here we show that the NOTCH pathway negatively modulates FAP differentiation both in vitro and in vivo. However, FAPs isolated from young dystrophin-deficient

Indexed as

AdipogenesisCell DifferentiationAdipocytesAnimalsBiomarkersDisease SusceptibilityFibrosisMiceMice, Inbred mdxModels, BiologicalMuscle Fibers, SkeletalPhenotypeProteomicsReceptors, NotchRegenerationSatellite Cells, Skeletal MuscleBiomarkersReceptors, Notch

Identifiers

PMID31239312
PMCPMC6599969
OpenAlexW2953862565

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.