Evidence map›Paper›PMID 31239270›Full record

ArticleCancer research2019

Guillermo Peluffo, Ashim Subedee, Nicholas W Harper, Natalie Kingston, Bojana Jovanović, Felipe Flores, Laura E Stevens, Francisco Beca, Anne Trinh, Chandra Sekhar Reddy Chilamakuri and 10 more

Open access · bronzeAbstract read
In one paragraph

Article in Cancer research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed, 1 pooled it
3.3field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 1 synthesis or guideline pooled it, 68 citations in OpenAlex.

  1. Pooled it
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  5. Review
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  7. Article
  8. Review
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  12. Article
  13. Engrailed-1 Promotes Pancreatic Cancer Metastasis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
    Article
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  15. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 5 institutions in 2 countries.

Guillermo Peluffo *Department of Medical Oncology, Dana-Farber Cancer Institute Boston, Massachusetts.
Ashim Subedee *Department of Medical Oncology, Dana-Farber Cancer Institute Boston, Massachusetts.
Nicholas W HarperDepartment of Medical Oncology, Dana-Farber Cancer Institute Boston, Massachusetts.ORCID 0000-0002-4037-7473
Natalie KingstonDepartment of Medical Oncology, Dana-Farber Cancer Institute Boston, Massachusetts.
Bojana JovanovićDepartment of Medical Oncology, Dana-Farber Cancer Institute Boston, Massachusetts.
Felipe FloresDepartment of Medical Oncology, Dana-Farber Cancer Institute Boston, Massachusetts.
Laura E StevensDepartment of Medical Oncology, Dana-Farber Cancer Institute Boston, Massachusetts.
Francisco BecaDepartment of Pathology, Harvard Medical School, Boston, Massachusetts.ORCID 0000-0002-4409-012X
Anne TrinhDepartment of Medical Oncology, Dana-Farber Cancer Institute Boston, Massachusetts.
Chandra Sekhar Reddy ChilamakuriCambridge Research Institute, University of Cambridge, Cambridge, United Kingdom.
Evangelia K PapachristouCambridge Research Institute, University of Cambridge, Cambridge, United Kingdom.ORCID 0000-0002-5835-2055
Katherine MurphyDepartment of Medical Oncology, Dana-Farber Cancer Institute Boston, Massachusetts.ORCID 0000-0002-5962-9896
Ying SuDepartment of Medical Oncology, Dana-Farber Cancer Institute Boston, Massachusetts.
Andriy MarusykDepartment of Medical Oncology, Dana-Farber Cancer Institute Boston, Massachusetts.
Clive S D'SantosCambridge Research Institute, University of Cambridge, Cambridge, United Kingdom.
Oscar M RuedaCambridge Research Institute, University of Cambridge, Cambridge, United Kingdom.ORCID 0000-0003-0008-4884
Andrew H BeckDepartment of Pathology, Harvard Medical School, Boston, Massachusetts.
Carlos CaldasCambridge Research Institute, University of Cambridge, Cambridge, United Kingdom.
Jason S CarrollCambridge Research Institute, University of Cambridge, Cambridge, United Kingdom.
Kornelia PolyakDepartment of Medical Oncology, Dana-Farber Cancer Institute Boston, Massachusetts. kornelia_polyak@dfci.harvard.edu.
Harvard University · USBridge University · SSDana-Farber Cancer Institute · USBeth Israel Deaconess Medical Center · USHarvard University Press · US

Funding

Targeting intratumor heterogeneity in breast cancerR35CA197623 · NCI · DANA-FARBER CANCER INST · PI KORNELIA POLYAK · 2015 to 2026
$12.4M
Cancer Research UK 16942Cancer Research UK 20411NCI NIH HHS R35 CA197623
6 · The paper itself

Abstract

To define transcriptional dependencies of triple-negative breast cancer (TNBC), we identified transcription factors highly and specifically expressed in primary TNBCs and tested their requirement for cell growth in a panel of breast cancer cell lines. We found that

Indexed as

Brain NeoplasmsCo-Repressor ProteinsFemaleGene Expression Regulation, NeoplasticHomeodomain ProteinsHumansMCF-7 CellsPrognosisTranscription FactorsTriple Negative Breast NeoplasmsXenograft Model Antitumor AssaysCo-Repressor ProteinsEN1 protein, humanHomeodomain ProteinsTLE3 protein, humanTranscription Factors

Identifiers

PMID31239270
PMCPMC6698222
OpenAlexW2954992176

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.