ArticleBMC cardiovascular disorders2019
Cortical thickness and cognitive performance in asymptomatic unilateral carotid artery stenosis.
Article in BMC cardiovascular disorders, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 20 citations in OpenAlex.
- Bilateral Cerebral Hypoperfusion in Asymptomatic Unilateral Carotid Artery Stenosis: An Arterial Spin Labeling MRI Study.Medicina (Kaunas, Lithuania) · 2025Article
- Cerebral Hemodynamic Impairment and Cognitive Dysfunction inJournal of the American Heart Association · 2025Observational
- An international, multispecialty, expert-based Delphi Consensus document on controversial issues in the management of patients with asymptomatic and symptomatic carotid stenosis.Journal of vascular surgery · 2024Review
- Alterations in brain morphology and functional connectivity mediate cognitive decline in carotid atherosclerotic stenosis.Frontiers in aging neuroscience · 2024Article
- Long-Term Resveratrol Intake for Cognitive and Cerebral Blood Flow Impairment in Carotid Artery Stenosis/Occlusion.Journal of stroke · 2024Article
- Examination of brain area volumes based on voxel-based morphometry and multidomain cognitive impairment in asymptomatic unilateral carotid artery stenosis.Frontiers in aging neuroscience · 2023Article
- Cortical Thinning in High-Grade Asymptomatic Carotid Stenosis.Journal of stroke · 2023Article
- Neuroimaging anomalies in asymptomatic middle cerebral artery steno-occlusive disease with normal-appearing white matter.Frontiers in neurology · 2023Article
- Asymptomatic carotid stenosis is associated with both edge and network reconfigurations identified by single-subject cortical thickness networks.Frontiers in aging neuroscience · 2022Article
- Integrating multiple brain imaging modalities does not boost prediction of subclinical atherosclerosis in midlife adults.NeuroImage. Clinical · 2022Article
- Microstructural Alterations Analogous to Accelerated Aging of the Cerebral Cortex in Carotid Occlusive Disease.Clinical neuroradiology · 2021Article
- Measurement of Cortical Atrophy and Its Correlation to Memory Impairment in Patients With Asymptomatic Carotid Artery Stenosis Based on VBM-DARTEL.Frontiers in aging neuroscience · 2021Article
- A New Rat Model of Chronic Cerebral Hypoperfusion Resulting in Early-Stage Vascular Cognitive Impairment.Frontiers in aging neuroscience · 2020Article
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Authors and funding
13 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWe investigated changes of cortical thickness and its association with cognitive performance in patients with high-grade carotid artery stenosis without ischemic brain lesions.
methodsWe studied 25 patients with unilateral carotid artery stenosis ≥50% and 25 age-matched controls. All subjects underwent T1-weighted MRI, and cortical thickness was measured in 33 regions of interest in each hemisphere, as well as in brain regions belonging to the vascular territory of the middle cerebral artery (MCA). General linear mixed models were fitted to the dependent variable cortical thickness. Cognitive assessment comprised the Stroop Test and Trail Making Test B.
resultsIn the linear mixed model, presence of carotid stenosis had no effect on cortical thickness. There was a significant interaction of stenosis and region with a trend towards lower cortical thickness in the MCA region on the side of carotid stenosis. Patients with carotid stenosis performed significantly worse on the Stroop test than controls, but there was no correlation with cortical thickness.
conclusionIn patients with carotid stenosis without ischemic brain lesions, neither a clear pattern of reduced cortical thickness nor an association of cortical thickness with cognitive function was observed. Our data do not support the hypothesized association of cortical thinning and cognitive impairment in carotid stenosis.
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