ArticleMicrobiome2019
Mining traits for the enrichment and isolation of not-yet-cultured populations.
Article in Microbiome, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Variations in deep-sea microbial composition and assembly mechanisms under different culture strategies.Frontiers in microbiology · 2026Article
- Clinical outcomes and psychosomatic correlates of integrative inpatient care based on Traditional Korean Medicine for acute neck and low back pain following traffic accidents: a retrospective cohort study.Frontiers in medicine · 2025Article
- Integrated genomics provides insights into the evolution of the polyphosphate accumulation trait ofEnvironmental science and ecotechnology · 2024Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe lack of pure cultures limits our understanding into 99% of bacteria. Proper interpretation of the genetic and the transcriptional datasets can reveal clues for the enrichment and even isolation of the not-yet-cultured populations. Unraveling such information requires a proper mining method.
resultsHere, we present a method to infer the hidden traits for the enrichment of not-yet-cultured populations. We demonstrate this method using Candidatus Accumulibacter. Our method constructs a whole picture of the carbon, electron, and energy flows in the not-yet-cultured populations from the genomic datasets. Then, it decodes the coordination across three flows from the transcriptional datasets. Based on it, our method diagnoses the status of the not-yet-cultured populations and provides strategy to optimize the enrichment systems.
conclusionOur method could shed light to the exploration into the bacterial dark matter in the environments.
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