Evidence map›Paper›PMID 31238941›Full record

ArticleParasites & vectors2019

High prevalence of Trypanosoma cruzi infection in shelter dogs from southern Louisiana, USA.

Ardem Elmayan, Weihong Tu, Brandy Duhon, Preston Marx, Wendy Wolfson, Gary Balsamo, Claudia Herrera, Eric Dumonteil

Open access · goldAbstract read
In one paragraph

Article in Parasites & vectors, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 2 pooled it
5.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 2 syntheses or guidelines pooled it, 62 citations in OpenAlex.

  1. Prevalence ofFrontiers in veterinary science · 2025
    Pooled it
  2. Pooled it
  3. Vaccines against chronicExpert review of vaccines · 2026
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  10. Identification of highly conservedEmerging microbes & infections · 2024
    Article
  11. Chagas Disease: A Silent Threat for Dogs and Humans.International journal of molecular sciences · 2024
    Review
  12. Validation of a multiplex microsphere immunoassay for detection of antibodies toJournal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc · 2023
    Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Locally TransmittedVector borne and zoonotic diseases (Larchmont, N.Y.) · 2021
    Article
  18. Parasitology · 2021
    Article
  19. Article
  20. AssessingPathogens (Basel, Switzerland) · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Ardem ElmayanDepartment of Tropical Medicine, School of Public Health and Tropical Medicine, Tulane University, New Orleans, Louisiana, USA.
Weihong TuDepartment of Tropical Medicine, School of Public Health and Tropical Medicine, Tulane University, New Orleans, Louisiana, USA.
Brandy DuhonSchool of Veterinary Medicine, Louisiana State University, Baton Rouge, Louisiana, USA.
Preston MarxDepartment of Tropical Medicine, School of Public Health and Tropical Medicine, Tulane University, New Orleans, Louisiana, USA.
Wendy WolfsonSchool of Veterinary Medicine, Louisiana State University, Baton Rouge, Louisiana, USA.
Gary BalsamoInfectious Disease Epidemiology Section, Office of Public Health, Department of Health, New Orleans, Louisiana, USA.
Claudia HerreraDepartment of Tropical Medicine, School of Public Health and Tropical Medicine, Tulane University, New Orleans, Louisiana, USA.
Eric DumonteilDepartment of Tropical Medicine, School of Public Health and Tropical Medicine, Tulane University, New Orleans, Louisiana, USA. edumonte@tulane.edu.
Tulane University · USLouisiana State University · USLouisiana State Department of Health and Hospitals · US

Funding

Tulane NPRC SPF Sheltered Outdoor Enclosure ExpansionP51OD011104 · OD · TULANE UNIVERSITY OF LOUISIANA · PI L Lee HAMM · 2012 to 2026
$142.4M
LSU-Tulane COBRE Center for Experimental Infectious Disease Research COBRENIH HHS P51 OD011104ODCDC CDC HHS P51 OD011104Tulane School of Public Health and Tropical Medicine 632083
6 · The paper itself

Abstract

backgroundChagas disease is a zoonotic disease caused by the protozoan parasite Trypanosoma cruzi. The role of dogs as sentinels has been proposed in multiple regions, as they are a domestic reservoir for T. cruzi. Our objective was to determine the prevalence of T. cruzi infection in shelter dogs from southern Louisiana, and assess its magnitude and distribution.

resultsA total of 540 dogs were enrolled, from 20 animal shelters, and tested for T. cruzi infection by serological tests (rapid test, ELISA and western blot) and PCR. We documented a high prevalence of T. cruzi infection with at least 6.9% (95% CI: 5.0-9.3%) seropositive and 15.7% (95% CI: 12.9-19.1%) PCR-positive dogs. Serological tests showed limited agreement, and concordance between serology and PCR was higher when considering reactivity to single serological tests. Trypanosoma cruzi infection was distributed evenly among shelters. Infection was significantly correlated with age (R

conclusionTrypanosoma cruzi infection is a significant and widespread veterinary problem in shelter dogs in the region, although it is mostly unnoticed by health professionals. This highlights the need for greater awareness of T. cruzi infection among the veterinary community and dog owners.

Indexed as

AnimalsAntibodies, ProtozoanChagas DiseaseDog DiseasesDogsEnzyme-Linked Immunosorbent AssayFemaleLouisianaMalePrevalenceSerologic TestsTrypanosoma cruziAntibodies, ProtozoanAmerican trypanosomiasisCanineChagas diseaseHeart diseaseParasite

Identifiers

PMID31238941
PMCPMC6593594
OpenAlexW2954301811

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.