Evidence map›Paper›PMID 31238916›Full record

ArticleBMC infectious diseases2019

Clusterization of co-morbidities and multi-morbidities among persons living with HIV: a cross-sectional study.

Paolo Maggi, Carmen R Santoro, Marco Nofri, Elena Ricci, Nicolò De Gennaro, Chiara Bellacosa, Elisabetta Schiaroli, Giancarlo Orofino, Barbara Menzaghi, Antonio Di Biagio and 7 more

Abstract read
In one paragraph

Article in BMC infectious diseases, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 1 synthesis or guideline pooled it.

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  18. The Prevalence and Burden of Non-AIDS Comorbidities Among Women Living With or at Risk for Human Immunodeficiency Virus Infection in the United States.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Paolo MaggiInfectious Diseases Clinic University of Campania "Luigi Vanvitelli", Neaples, Italy.
Carmen R SantoroInfectious Diseases Clinic, University of Bari, Bari, Italy.
Marco NofriInfectious Diseases Clinic, Department of Medicine 2, Azienda Ospedaliera di Perugia and University of Perugia, Santa Maria Hospital, Perugia, Italy.
Elena RicciDepartment of Women, Child and Neonate, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy. ed.ricci@libero.it.ORCID http://orcid.org/0000-0001-5279-0444
Nicolò De GennaroInfectious Diseases Clinic, University of Bari, Bari, Italy.
Chiara BellacosaInfectious Diseases Clinic, University of Bari, Bari, Italy.
Elisabetta SchiaroliInfectious Diseases Clinic, Department of Medicine 2, Azienda Ospedaliera di Perugia and University of Perugia, Santa Maria Hospital, Perugia, Italy.
Giancarlo OrofinoDivision I of Infectious and Tropical Diseases, ASL Città di Torino, Torino, Italy.
Barbara MenzaghiUnit of Infectious Diseases, ASST della Valle Olona, Busto Arsizio, VA, Italy.
Antonio Di BiagioInfectious Diseases, San Martino Hospital Genoa, Genoa, Italy.
Nicola SquillaceInfectious Diseases Unit ASST-MONZA, San Gerardo Hospital-University of Milano-Bicocca, Monza, Italy.
Daniela FrancisciInfectious Diseases Clinic, Department of Medicine 2, Azienda Ospedaliera di Perugia and University of Perugia, Santa Maria Hospital, Perugia, Italy.
Francesca VichiInfectious Diseases Unit, Santa Maria Annunziata Hospital, Usl centro, Florence, Italy.
Chiara MolteniUnit of Infectious Diseases, A. Manzoni Hospital, Lecco, Italy.
Paolo BonfantiUnit of Infectious Diseases, A. Manzoni Hospital, Lecco, Italy.
Giovanni Battista GaetaInfectious Diseases Clinic University of Campania "Luigi Vanvitelli", Neaples, Italy.
Giuseppe Vittorio De SocioInfectious Diseases Clinic, Department of Medicine 2, Azienda Ospedaliera di Perugia and University of Perugia, Santa Maria Hospital, Perugia, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAmong people living with HIV (PLWH), the prevalence of non-HIV related co-morbidities is increasing. Aim of the present study is to describe co-morbidity and multi-morbidity, their clustering mode and the potential disease-disease interactions in a cohort of Italian HIV patients.

methodsCross-sectional analysis conducted by the Coordinamento Italiano per lo Studio di Allergia e Infezioni da HIV (CISAI) on adult subjects attending HIV-outpatient facilities. Non-HIV co-morbidities included: cardiovascular disease, diabetes mellitus, hypertension, oncologic diseases, osteoporosis, probable case of chronic obstructive pulmonary disease (COPD), hepatitis C virus (HCV) infection, psychiatric illness, kidney disease. Multi-morbidity was defined as the presence of two or more co-morbidities.

resultsOne thousand and eighty-seven patients were enrolled in the study (mean age 47.9 ± 10.8). One hundred-ninety patients (17.5%) had no co-morbidity, whereas 285 (26.2%) had one condition and 612 (56.3%) were multi-morbid. The most recurrent associations were: 1) dyslipidemia + hypertension (237, 21.8%); 2) dyslipidemia + COPD (188, 17.3%); 3) COPD + HCV-Ab+ (141, 12.9%). Multi-morbidity was associated with older age, higher body mass index, current and former smoking, CDC stage C and longer ART duration.

conclusionsMore than 50% of PLHW were multi-morbid and about 30% had three or more concurrent comorbidities. The identification of common patterns of comorbidities address the combined risks of multiple drug and disease-disease interactions.

Indexed as

MultimorbidityAdultAgedAIDS-Related Opportunistic InfectionsCardiovascular DiseasesCluster AnalysisCohort StudiesComorbidityCross-Sectional StudiesDiabetes MellitusFemaleHIVHIV InfectionsHumansHypertensionItalyClusterizationCo-morbidityDisease-disease interactionsHIVMulti-morbidity

Identifiers

PMID31238916
PMCPMC6593514

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.