Evidence map›Paper›PMID 31238911›Full record

ArticleBMC public health2019

HPV vaccination has not increased sexual activity or accelerated sexual debut in a college-aged cohort of men and women.

Andrew F Brouwer, Rachel L Delinger, Marisa C Eisenberg, Lora P Campredon, Heather M Walline, Thomas E Carey, Rafael Meza

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC public health, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 4 pooled it
6.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 4 syntheses or guidelines pooled it, 82 citations in OpenAlex.

  1. Pooled it
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  4. Sexually Transmitted Infections Treatment Guidelines, 2021.MMWR. Recommendations and reports : Morbidity and mortality weekly report. Recommendations and reports · 2021
    Guideline
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  19. Provider Confidence and Perceived Barriers when Recommending the Human Papillomavirus Vaccine to Parents.Journal of cancer education : the official journal of the American Association for Cancer Education · 2023
    Article
  20. Preferences for Sexually Transmitted Infection and Cancer Vaccines in the United States and in China.Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Andrew F BrouwerDepartment of Epidemiology, University of Michigan, 1415 Washington Heights, Ann Arbor, MI, 48109, USA. brouweaf@umich.edu.ORCID http://orcid.org/0000-0002-3779-5287
Rachel L DelingerDepartment of Epidemiology, University of Michigan, 1415 Washington Heights, Ann Arbor, MI, 48109, USA.
Marisa C EisenbergDepartment of Epidemiology, University of Michigan, 1415 Washington Heights, Ann Arbor, MI, 48109, USA.
Lora P CampredonDepartment of Epidemiology, University of Michigan, 1415 Washington Heights, Ann Arbor, MI, 48109, USA.
Heather M WallineDepartment of Otolaryngology, University of Michigan, 1500 E. Medical Center Dr., Ann Arbor, MI, 48109, USA.
Thomas E CareyDepartment of Otolaryngology, University of Michigan, 1500 E. Medical Center Dr., Ann Arbor, MI, 48109, USA.
Rafael MezaDepartment of Epidemiology, University of Michigan, 1415 Washington Heights, Ann Arbor, MI, 48109, USA.
University of Michigan · US

Funding

Mechanistic Modeling of Oropharyngeal Cancer Treatment and Recurrence (Supplement)U01CA182915 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI EISENBERG, MARISA C, MEZA, RAFAEL · 2014 to 2019
$3.3M
Molecular Mechanisms of Tumor Behavior and Response to Therapy in HPV-positive Oropharyngeal CancerR01CA194536 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CAREY, THOMAS E. · 2016 to 2021
$2.8M
NCI NIH HHS R01 CA194536NCI NIH HHS U01 CA182915NCI NIH HHS U01CA182915
6 · The paper itself

Abstract

backgroundThe human papillomavirus (HPV) is the most common sexually transmitted infection and is linked to several types of cancer. HPV vaccination uptake in the U.S. is relatively low, despite the vaccine's high efficacy. Some parents of adolescents have concerns that vaccination will encourage sexual behavior and therefore choose not to vaccinate. Previous studies investigating vaccination and sexual behavior have included only young women and girls.

methodsThe objective of this study is to assess associations between HPV-vaccination and sexual behavior in a college-age cohort of both men and women. We analyzed questionnaire data collected from the Michigan HPV and Oropharyngeal Cancer Study, a cohort study designed to investigate HPV infection and its association with sexual behavior (data collected 2015-17, Ann Arbor, MI). Here, we consider vaccination status, sexual behavior, and substance use among 241 college-aged men and women. Logistic, Poisson, and Cox regression were used to determine the relationship between probability of sexual debut, number of sexual partners, and HPV vaccination status at baseline as well as between age at sexual debut and vaccination status at debut.

resultsHPV vaccination status was not significantly associated with an increased likelihood of sexual debut (odds ratio: 0.80 (95% CI: 0.41-1.58), decreased age of sexual debut (hazard ratio: 0.81 (95% CI: 0.65-1.00), nor an increased number of sexual partners (per year sexually active; incidence rate ratio: 1.27 (95% CI: 0.86-1.87)) in this cohort, after controlling for age, race, sex, and substance use. Instead, race or alcohol use were independent predictors of sexual behavior.

conclusionsConcerns about the influence of the HPV vaccine on sexual behavior are likely unfounded for both men and women. These results can aid in increasing vaccine acceptability, inform and strengthen physician recommendations, and ultimately reduce the burden of HPV and HPV-related cancers in the U.S.

Indexed as

AdolescentCohort StudiesFemaleHumansMaleMichiganPapillomavirus VaccinesSexual BehaviorUniversitiesYoung AdultPapillomavirus VaccinesCohort studyCollege-aged populationHPV vaccineHuman papillomavirusM-HOC studySexual behavior

Identifiers

PMID31238911
PMCPMC6593582
OpenAlexW2954837286

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.