Evidence map›Paper›PMID 31238895›Full record

ArticleBMC cancer2019

Serum chitinase activity prognosticates metastasis of colorectal cancer.

Zhangfa Song, Engeng Chen, Jun Qian, Jianbin Xu, Gaoyang Cao, Wei Zhou, Fei Wang, Min Chen, Dengyong Xu, Xiaowei Wang and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC cancer, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.3field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 6 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 1 country.

Zhangfa SongDepartment of Colorectal Surgery, Sir Run Run Shaw Hospital of Zhejiang University, Hangzhou, 310016, China. songzhangfa@zju.edu.cn.ORCID http://orcid.org/0000-0001-6301-1813
Engeng ChenDepartment of Colorectal Surgery, Sir Run Run Shaw Hospital of Zhejiang University, Hangzhou, 310016, China.
Jun QianDepartment of colorectal surgery, Xinchang Hospital, Xinchang, China.
Jianbin XuZhejiang Province Key Laboratory of Biological Treatment, Hangzhou, China.
Gaoyang CaoDepartment of Colorectal Surgery, Sir Run Run Shaw Hospital of Zhejiang University, Hangzhou, 310016, China.
Wei ZhouDepartment of Colorectal Surgery, Sir Run Run Shaw Hospital of Zhejiang University, Hangzhou, 310016, China.
Fei WangDepartment of Colorectal Surgery, Sir Run Run Shaw Hospital of Zhejiang University, Hangzhou, 310016, China.
Min ChenDepartment of Colorectal Surgery, Sir Run Run Shaw Hospital of Zhejiang University, Hangzhou, 310016, China.
Dengyong XuDepartment of Colorectal Surgery, Sir Run Run Shaw Hospital of Zhejiang University, Hangzhou, 310016, China.
Xiaowei WangDepartment of Colorectal Surgery, Sir Run Run Shaw Hospital of Zhejiang University, Hangzhou, 310016, China.
Xiaotong HuZhejiang Province Key Laboratory of Biological Treatment, Hangzhou, China.
Zhenyu JuKey Laboratory of Regenerative Medicine of Ministry of Education, Institute of Aging and Regenerative Medicine, Jinan University, Guangzhou, China.
Xuefeng HuangDepartment of Colorectal Surgery, Sir Run Run Shaw Hospital of Zhejiang University, Hangzhou, 310016, China.
Xiujun CaiDepartment of General Surgery, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, 310016, China. srrsh_cxj@zju.edu.cn.
Sir Run Run Shaw Hospital · CNBlood Center of Zhejiang Province · CNJinan University · CN

Funding

Medical and Health Science and Technology Project of Zhejiang Provincial Health Commission Nos. 2018KY473 & 2018PY025National Natural Science Foundation of China 81701820National Natural Science Foundation of China 81771502
6 · The paper itself

Abstract

backgroundThis study aimed to evaluate the value of chitinase activity in prognosticating the occurrence of metastasis in and prognosis of patients with colorectal cancer (CRC).

methodsThe chitinase activity in four different groups, namely 335 CRC patients without distant metastasis at their first visit (Group 1), 51 patients with CRC having synchronous liver metastasis (Group 2), 100 healthy age-matched controls (Group 3) and 40 patients with liver cancer (Group 4), were assayed using an enzyme-linked immunosorbent assay. The Cox proportional hazards ratio model and Kaplan-Meier curve were used to identify the association between chitinase activity and the clinical outcome of CRC patients without metastasis in the training set and testing set at their first visit. An in vitro Transwell experiment was performed to evaluate the migration of colon cancer cells.

resultsPatients with high chitinase activity had a significantly higher metastasis risk than those with low chitinase activity in the training and testing sets during follow-up, both at stage I/II and stage III. Further, multivariate analysis revealed that chitinase activity was an independent risk factor prognosticating liver metastases (P = 0.001). The combination of chitinase activity and lymph node metastasis status increased the accuracy of the prognosis of liver metastases after radical resection (P = 0.454E-011). In addition, chitinase promoted CRC cell migration in vitro.

conclusionsChitinase activity can prognosticate the occurrence of metastasis in patients with CRC. Moreover, the combination of chitinase activity and N stage increased the power of prognosticating the occurrence of metastasis. Inhibiting chitinase activity may serve as a new strategy to treat metastases of CRC.

Indexed as

Biomarkers, TumorCase-Control StudiesCell Line, TumorCell MovementChitinasesColonic NeoplasmsEnzyme-Linked Immunosorbent AssayFemaleHumansKaplan-Meier EstimateLiver NeoplasmsMaleMiddle AgedMultivariate AnalysisNeoplasm StagingPrognosisBiomarkers, TumorChitinasesBiomarkerChitinase activityColorectal CancerMetastasis

Identifiers

PMID31238895
PMCPMC6593502
OpenAlexW2954113338

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.