ArticleBMC cancer2019
Risk factor analysis for predicting cervical lymph node metastasis in papillary thyroid carcinoma: a study of 966 patients.
Article in BMC cancer, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 150 papers, 4 of them syntheses that pooled it.
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Who cites it
150 citing papers in PubMed, 4 syntheses or guidelines pooled it, 235 citations in OpenAlex.
- Meta-analysis of prediction models for predicting lymph node metastasis in thyroid cancer.World journal of surgical oncology · 2024Pooled it
- Meta-analysis of the effect and clinical significance of Delphian lymph node metastasis in papillary thyroid cancer.Frontiers in endocrinology · 2023Pooled it
- Clinicopathological Significance of Papillary Thyroid Carcinoma Located in the Isthmus: A Meta-Analysis.World journal of surgery · 2021Pooled it
- Risk Factors for Lymph Node Metastasis in Papillary Thyroid Carcinoma: A Systematic Review and Meta-Analysis.Frontiers in endocrinology · 2020Pooled it
- Therapeutic Strategy in Low-Risk Papillary Thyroid Carcinoma - Long-Term Results of the First Single-Center Prospective Non-Randomized Trial Between 2011 and 2015.Frontiers in endocrinology · 2021Trial
- Article
- Preoperative predictors of occult central lymph node metastasis in clinically node-negative papillary thyroid carcinoma: a common data model-based retrospective cohort study.Annals of surgical treatment and research · 2026Article
- Article
- Development of a clinically applicable prediction tool for lymph node metastasis in papillary thyroid carcinoma using lasso-logistic regression.BMC cancer · 2026Article
- Clinical significance of multimodal ultrasound features in predicting cervical lymph node metastasis in papillary thyroid carcinoma with cystic change.Quantitative imaging in medicine and surgery · 2026Article
- Can Whole-Thyroid-Based CT Radiomics Model Achieve the Performance of Lesion-Based Model in Predicting the Thyroid Nodules Malignancy? - A Comparative Study.Journal of imaging informatics in medicine · 2026Article
- Comparison of ultrasound-guided biopsy techniques for level IV lymph nodes: semiautomatic vs. Menghini modified needles in a retrospective dual-center study.BMC medical imaging · 2026Article
- Article
- Surgical Optimization in Preoperatively Low-risk cN1a PTC: A Predictive Model for High-Volume Central Lymph Node Metastasis.Annals of surgical oncology · 2026Article
- Risk factors for lateral and skip lymph node metastasis in adolescents and young adults with papillary thyroid carcinoma.Gland surgery · 2026Article
- Construction and application of a nomogram model for early stage central lymph node metastasis in papillary thyroid cancer combined with Hashimoto's thyroiditis.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas · 2026Article
- Clinicopathological landscape and management trends of thyroid carcinoma over two decades: a single-institution study and risk stratification of central lymph node metastasis in T1 papillary thyroid carcinoma.Frontiers in endocrinology · 2026Article
- The clinical value of Delphian and pre-tracheal lymph nodes in predicting lateral lymph nodes metastasis of papillary thyroid carcinoma.Annals of medicine · 2025Article
- The relationship between the extent of extrathyroidal extension and lymph node metastasis based on propensity score matching analysis.Gland surgery · 2025Article
- Preoperative multiparametric ultrasound for the prediction of central lymph node metastasis in papillary thyroid carcinoma.Quantitative imaging in medicine and surgery · 2025Article
90 more citing papers are in PubMed but not listed here.
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
backgroundsThe aim of this study is to investigate the risk factors for the cervical lymph node metastasis in papillary thyroid carcinoma (PTC).
methodsThe clinicopathological data from the 966 PTC patients who underwent thyroid operation between January 2013 and December 2015 in the general surgery department of Shengjing Hospital of China Medical University were collected. The risk factors of predicting cervical lymph node metastasis were analyzed.
resultsMale, age ≤ 45 years old, tumor size> 1.0 cm, extrathyroidal extension (ETE), US features as microcalcification, were independent risk factors for central lymph node metastasis (CLNM) (P < 0.05). Only CLNM was independent risk factors for lateral lymph node metastasis (LLNM) (P < 0.05). The ROC curve showed that the cutoff value of the number of CLNM for predicting lateral lymph node metastasis was defined as 2.5 (Sensitivity = 0.535, Specificity = 0.722, AUC = 0.669, P < 0.05). When the number of CLNM > 3, OR value was significantly higher, suggesting that the risk of LLNM increased significantly. The incidence of LLNM in level III (66.8%) and level IV (67.3%) were significantly higher than level II (42.2%) and level V (21.3%) (P < 0.05). The incidence of LLNM and skip metastasis in tumor located in the upper 1/3 of the lobe was the highest (P < 0.05).
conclusionsProphylactic central lymph node dissection should be performed in patients with risk factors as male, age ≤ 45 years old, tumor size> 1.0 cm, ETE and US features as microcalcification. Lateral lymph node dissection (LLND) should be more actively performed in patients with the number of CLNM> 3. Extent of LLND should include levels II, III, IV and V. Tumor located in the upper 1/3 of the lobe was vulnerable for LLNM and skip metastasis, so lymph node in lateral compartment should be noticed when lymph node status was preoperatively evaluated by imaging examination.
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