ArticleBiology letters2019
Exploring the lower thermal limits for development of the human malaria parasite, Plasmodium falciparum.
Article in Biology letters, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed.
- Phenotypic variation in populations of the mosquito vector, Aedes aegypti, and implications for predicting the effects of temperature and climate change on dengue transmission.PLoS neglected tropical diseases · 2025Article
- Modelling the effects of diurnal temperature variation on malaria infection dynamics in mosquitoes.Communications biology · 2025Article
- Climate Change and Malaria: A Call for Robust Analytics.medRxiv : the preprint server for health sciences · 2025Article
- Organ Tropism ofPathogens (Basel, Switzerland) · 2024Article
- Influence of future climate scenarios using CMIP 5 data on malaria transmission in India.Malaria journal · 2024Article
- Warming alters life-history traits and competition in a phage community.Applied and environmental microbiology · 2024Article
- Estimating the effects of temperature on transmission of the human malaria parasite, Plasmodium falciparum.Nature communications · 2024Article
- Effects of Temperature and Nutrition during the Larval Period on Life History Traits in an Invasive Malaria VectorInsects · 2023Article
- Plasmodium vivax: the potential obstacles it presents to malaria elimination and eradication.Tropical diseases, travel medicine and vaccines · 2022Review
- Inference and dynamic simulation of malaria using a simple climate-driven entomological model of malaria transmission.PLoS computational biology · 2022Article
- Predicting malaria outbreaks from sea surface temperature variability up to 9 months ahead in Limpopo, South Africa, using machine learning.Frontiers in public health · 2022Article
- Dry Post Wintertime Mass Surveillance Unearths a Huge Burden ofPathogens (Basel, Switzerland) · 2021Article
- Impact of an accelerated melting of Greenland on malaria distribution over Africa.Nature communications · 2021Article
- Malaria trends in Ethiopian highlands track the 2000 'slowdown' in global warming.Nature communications · 2021Article
- Incorporating hydrology into climate suitability models changes projections of malaria transmission in Africa.Nature communications · 2020Article
- Potential for Zika virus transmission by mosquitoes in temperate climates.Proceedings. Biological sciences · 2020Article
- The influence of feeding behaviour and temperature on the capacity of mosquitoes to transmit malaria.Nature ecology & evolution · 2020Article
- Thermal biology of mosquito-borne disease.Ecology letters · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
The rate of malaria transmission is strongly determined by parasite development time in the mosquito, known as the extrinsic incubation period (EIP), since the quicker parasites develop, the greater the chance that the vector will survive long enough for the parasite to complete development and be transmitted. EIP is known to be temperature-dependent but this relationship is surprisingly poorly characterized. There is a single degree-day model for EIP of Plasmodium falciparum that derives from a limited number of poorly controlled studies conducted almost a century ago. Here, we show that the established degree-day model greatly underestimates the rate of development of P. falciparum in both Anopheles stephensi and An. gambiae mosquitoes at temperatures in the range of 17-20°C. We also show that realistic daily temperature fluctuation further speeds parasite development. These novel results challenge one of the longest standing models in malaria biology and have potentially important implications for understanding the impacts of future climate change.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.