Evidence map›Paper›PMID 31238601›Full record

ArticleMetabolites2019

Identifying Metabolomic Profiles of Insulinemic Dietary Patterns.

Fred K Tabung, Raji Balasubramanian, Liming Liang, Steven K Clinton, Elizabeth M Cespedes Feliciano, JoAnn E Manson, Linda Van Horn, Jean Wactawski-Wende, Clary B Clish, Edward L Giovannucci and 1 more

Open access · goldAbstract read
In one paragraph

Article in Metabolites, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 21 citations in OpenAlex.

  1. Trial
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 8 institutions in 1 country.

Fred K TabungDivision of Medical Oncology, Department of Internal Medicine, The Ohio State University College of Medicine, Columbus, OH 43210, USA. fred.tabung@osumc.edu.ORCID 0000-0001-8193-7150
Raji BalasubramanianDepartment of Biostatistics and Epidemiology, University of Massachusetts-Amherst, MA 01003, USA. rbalasub@umass.edu.
Liming LiangDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA. lliang@hsph.harvard.edu.
Steven K ClintonDivision of Medical Oncology, Department of Internal Medicine, The Ohio State University College of Medicine, Columbus, OH 43210, USA. Steven.Clinton@osumc.edu.
Elizabeth M Cespedes FelicianoDivision of Research, Kaiser Permanente Northern California, Oakland, CA 94612, USA. Elizabeth.M.Cespedes@kp.org.ORCID 0000-0003-1192-4017
JoAnn E MansonDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA. jmanson@rics.bwh.harvard.edu.
Linda Van HornDepartment of Preventive Medicine, Northwestern University, Chicago, IL 60611, USA. lvanhorn@northwestern.edu.
Jean Wactawski-WendeDepartment of Epidemiology and Environmental Health, University at Buffalo, The State University of New York, Buffalo, NY 14214, USA. jww@buffalo.edu.
Clary B ClishBroad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02142, USA. clary@broadinstitute.org.
Edward L GiovannucciDepartment of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA. egiovann@hsph.harvard.edu.
Kathryn M RexrodeDivision of Women's Health, Brigham and Women's Hospital, Boston, MA 02115, USA. krexrode@bwh.harvard.edu.
Brigham and Women's Hospital · USHarvard University · USBroad Institute · USKaiser Permanente · USNorthwestern University · USThe Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute · USUniversity at Buffalo, State University of New York · USUniversity of Massachusetts Amherst · US

Funding

ROLE OF DIETARY CONSTITUENTS ON GENE EXPRESSION IN INTESTINAL EPITHELIUMP30DK040561 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI Elizabeth Austen Lawson, Takara Leah Stanley · 1994 to 2026
$31.6M
RISK FACTORS FOR CVD IN WOMENR01HL034594 · NHLBI · TULANE UNIVERSITY OF LOUISIANA · PI JoAnn Elisabeth Manson, Lu Qi · 1985 to 2026
$13.8M
Pro-inflammatory and Hyper-insulinemic Dietary Patterns and Colorectal Cancer Risk: Role of the MetabolomeR00CA207736 · NCI · OHIO STATE UNIVERSITY · PI TABUNG, FRED KINYUY · 2018 to 2020
$747k
NCI NIH HHS R00 CA207736NCI NIH HHS R00CA207736NHLBI NIH HHS HHSN268201600018C, HHSN268201600001C, HHSN268201600002C, HHSN268201600003C and HHSN268201600004CNHLBI NIH HHS R01 HL034594NIDDK NIH HHS P30 DK040561
6 · The paper itself

Abstract

The food-based empirical dietary index for hyperinsulinemia (EDIH) score assesses the insulinemic potential of diet. This cross-sectional study evaluated associations between EDIH scores from food frequency questionnaires with c-peptide concentrations and with 448 metabolites, from fasting plasma samples, in multivariable linear regression analyses. Metabolites were measured with liquid chromatography tandem mass spectroscopy. Using a robust two-stage study design, discovery of metabolite associations was conducted among 1109 Women's Health Initiative (WHI) Hormone Therapy (HT) trial participants and results replicated in an independent dataset of 810 WHI Observational Study (OS) participants. In both discovery and replication datasets, statistical significance was based on the false-discovery rate adjusted

Indexed as

dietary patternsinsulinemic dietsmetabolomicspostmenopausal women

Identifiers

PMID31238601
PMCPMC6630814
OpenAlexW2952591659

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.