ReviewPharmaceuticals (Basel, Switzerland)2019
Psychotropic Drugs for the Management of Chronic Pain and Itch.
Review in Pharmaceuticals (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 40 citations in OpenAlex.
- Preparation and evaluation of citalopram novasomal vesicles as a transdermal analgesic drug delivery.Drug delivery and translational research · 2026Article
- Patient-Reported Pain and Itch Scores After a Course of Laser Therapy for the Treatment of Postburn Hypertrophic Scar Are Impacted by Mental Health Status.Journal of burn care & research : official publication of the American Burn Association · 2025Article
- The impact of opioid analgesics with concomitant antipsychotic use on pain modulation and management in internal medicine: a cross-sequential study protocol.Frontiers in pain research (Lausanne, Switzerland) · 2025Article
- The additive effect between citalopram and muscimol upon induction of antinociceptive effect in male mice.IBRO neuroscience reports · 2024Article
- Calcium-Dependent Interplay of Lithium and Tricyclic Antidepressants, Amitriptyline and Desipramine, onInternational journal of molecular sciences · 2022Article
- Nutritional and Metabolic Factors, Ethanol and Cholesterol, Interact With Calcium-DependentFrontiers in cellular neuroscience · 2022Article
- Editorial: Pain-related neural networks and regulation mechanisms.Frontiers in molecular neuroscience · 2022Article
- Characteristics, mechanism, and management of pain in atopic dermatitis: A literature review.Clinical and translational allergy · 2021Review
- Trazodone effects on developing brain.Translational psychiatry · 2021Article
- Doxepin prevents the Expression and Development of Paclitaxel-Induced Neuropathic Pain.Advanced biomedical research · 2021Article
- Tricyclic Antidepressant Structure-Related Alterations in Calcium-Dependent Inhibition and Open-Channel Block of NMDA Receptors.Frontiers in pharmacology · 2021Article
- Attenuation of the Diffuse Noxious Inhibitory Controls in Chronic Joint Inflammatory Pain Is Accompanied by Anxiodepressive-Like Behaviors and Impairment of the Descending Noradrenergic Modulation.International journal of molecular sciences · 2020Article
- Mechanisms for Reducing Neuropathic Pain.Molecular neurobiology · 2020Review
- Neuropharmacological Effects of Mesaconitine: Evidence from Molecular and Cellular Basis of Neural Circuit.Neural plasticity · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
Clinical observations have shown that patients with chronic neuropathic pain or itch exhibit symptoms of increased anxiety, depression and cognitive impairment. Such patients need corrective therapy with antidepressants, antipsychotics or anticonvulsants. It is known that some psychotropic drugs are also effective for the treatment of neuropathic pain and pruritus syndromes due to interaction with the secondary molecular targets. Our own clinical studies have identified antipruritic and/or analgesic efficacy of the following compounds: tianeptine (atypical tricyclic antidepressant), citalopram (selective serotonin reuptake inhibitor), mianserin (tetracyclic antidepressant), carbamazepine (anticonvulsant), trazodone (serotonin antagonist and reuptake inhibitor), and chlorprothixene (antipsychotic). Venlafaxine (serotonin-norepinephrine reuptake inhibitor) is known to have an analgesic effect too. The mechanism of such effect of these drugs is not fully understood. Herein we review and correlate the literature data on analgesic/antipruritic activity with pharmacological profile of these compounds.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.