ArticleDrug and alcohol dependence2019
Economic demand analysis of within-session dose-reduction during nicotine self-administration.
Article in Drug and alcohol dependence, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 12 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
12 citing papers in PubMed.
- An evaluation of N-acetylcysteine in a sequential oxycodone and cocaine rat self-administration model.Experimental and clinical psychopharmacology · 2026Article
- Preclinical abuse potential testing using behavioral economics and drug self-administration demand-curve analysis: A strategy to improve resolution of drug stratification for regulatory control.Pharmacological reviews · 2026Review
- Human laboratory models of reward in substance use disorder.Pharmacology, biochemistry, and behavior · 2024Review
- Synthetic contraceptive hormones occlude the ability of nicotine to reduce ethanol consumption in ovary-intact female rats.Drug and alcohol dependence · 2023Article
- Neurobehavioral effects of environmental enrichment and drug abuse vulnerability: An updated review.Pharmacology, biochemistry, and behavior · 2022Review
- Logical fallacies and misinterpretations that hinder progress in translational addiction neuroscience.Journal of the experimental analysis of behavior · 2022Article
- Nuclear factor kappa B signaling within the rat nucleus accumbens core sex-dependently regulates cue-induced cocaine seeking and matrix metalloproteinase-9 expression.Brain, behavior, and immunity · 2022Article
- Effects of NMDA receptor antagonists on behavioral economic indices of cocaine self-administration.Drug and alcohol dependence · 2022Article
- Strain and sex matters: Differences in nicotine self-administration between outbred and recombinase-driver transgenic rat lines.Experimental and clinical psychopharmacology · 2021Article
- Behavioral economic demand as a unifying language for addiction science: Promoting collaboration and integration of animal and human models.Experimental and clinical psychopharmacology · 2020Review
- Environmental enrichment during forced abstinence from cocaine self-administration opposes gene network expression changes associated with the incubation effect.Scientific reports · 2020Article
- Nicotine reduction does not alter essential value of nicotine or reduce cue-induced reinstatement of nicotine seeking.Drug and alcohol dependence · 2020Article
Corrections and comments
- Erratum issued
Authors and funding
7 authors.
Funding
Abstract
backgroundThis study determined if a within-session dose-reduction design sufficiently captures elasticity of demand for nicotine in male and female rats using environmental enrichment to manipulate demand elasticity.
methodsMale and female Sprague-Dawley rats were trained to self-administer nicotine (60 μg/kg/infusion). In Experiment 1, rats began daily dose-reduction for nine sessions following acquisition. Rats then underwent a minimum of five within-session dose-reduction sessions where each dose was available for 10 min. In Experiment 2, rats were reared in isolated, social, or enriched housing followed by acquisition of nicotine self-administration. Rats then underwent within-session dose-reduction. Housing environments were then switched, followed by additional testing sessions. Consumption was calculated for each dose and exponential demand curves were fit.
resultsNo sex differences in acquisition of nicotine self-administration were detected for either experiment. In experiment 1, demand intensity (Q
conclusionsThe within-session dose-reduction procedure for nicotine self-administration replicated effects of environmental enrichment on consumption behaviors. Additionally, this procedure captured differences in nicotine demand due to sex, laying important groundwork for future translational research on mechanisms of nicotine dependence.
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