Evidence map›Paper›PMID 31238203›Full record

Trial reportJournal of psychiatric research2019

Prevalence of obstructive sleep apnea in suicidal patients with major depressive disorder.

William V McCall, Ruth M Benca, Meredith E Rumble, Doug Case, Peter B Rosenquist, Andrew D Krystal

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of psychiatric research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01689909 (Reducing Suicidal Ideation Through Insomnia Treatment), which is not on this map. Cited by 11 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01689909 phase4completednot on this map

Reducing Suicidal Ideation Through Insomnia Treatment

TypeinterventionalSponsorAugusta UniversityRan2012 to 2018Enrolled103ConditionsInsomnia, Depression, Suicidal IdeationArmsZolpidem-CR, Placebo
3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Distinct functional brain abnormalities in insomnia disorder and obstructive sleep apnea.European archives of psychiatry and clinical neuroscience · 2023
    Pooled it
  2. Pooled it
  3. Trial
  4. Trial
  5. Review
  6. Article
  7. Intravenous ketamine for benzodiazepine deprescription and withdrawal management in treatment-resistant depression: a preliminary report.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023
    Article
  8. Article
  9. Depression scores improve with continuous positive airway pressure in specialized sleep clinics: real-world data.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2021
    Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

William V McCallThe Department of Psychiatry and Health Behavior, Medical College of Georgia at Augusta University, Augusta, GA, USA. Electronic address: wmccall@augusta.edu.
Ruth M BencaDepartment of Psychiatry and Human Behavior, University of California, Irvine, Irvine, CA, USA. Electronic address: rbenca@uci.edu.
Meredith E RumbleDepartment of Psychiatry, University of Wisconsin, Madison, WI, USA. Electronic address: rumble@wisc.edu.
Doug Case. Department of Biostatistics and Data Sciences, Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC, USA. Electronic address: dcase@wakehealth.edu.
Peter B RosenquistThe Department of Psychiatry and Health Behavior, Medical College of Georgia at Augusta University, Augusta, GA, USA.
Andrew D KrystalUniversity of California San Francisco, San Francisco, CA, USA. Electronic address: andrew.krystal@ucsf.edu.

Funding

1/3-Reducing Suicial Ideation Through Insomnia Treatment (REST-IT)R01MH095776 · NIMH · AUGUSTA UNIVERSITY · PI MCCALL, WILLIAM VAUGHN · 2012 to 2016
$1.2M
3/3-Reducing Suicidal Ideation Through Insomnia Treatment (REST-IT)R01MH095778 · NIMH · UNIVERSITY OF WISCONSIN-MADISON · PI BENCA, RUTH M · 2012 to 2016
$991k
2/3-Reducing Suicide Ideation Through Insomnia Treatment (REST-IT)R01MH095780 · NIMH · DUKE UNIVERSITY · PI KRYSTAL, ANDREW D · 2012 to 2016
$904k
NIMH NIH HHS R01 MH095776NIMH NIH HHS R01 MH095778NIMH NIH HHS R01 MH095780
6 · The paper itself

Abstract

In this paper, we report the rate of previously undiagnosed obstructive sleep apnea (OSA) in a randomized clinical trial (RCT) of suicidal patients with major depressive disorder (MDD). One hundred and twenty-five suicidal adults with MDD were recruited into a RCT. None were suspected to have OSA. Fourteen percent met diagnostic criteria for OSA. The Apnea Hypopnea Index (AHI) was predicted by increasing age, male sex, and higher Body Mass Index. However, neither the degree of daytime sleepiness nor the degree of insomnia predicted AHI severity. A high degree of suspicion is warranted for OSA in suicidal patients with MDD, and for patients with treatment-resistant depression. ClinicalTrials.gov identifier: NCT01689909.

Indexed as

Suicidal IdeationAdultComorbidityDepressive Disorder, Treatment-ResistantFemaleHumansMajor Depressive DisorderMaleMiddle AgedPrevalenceSleep Apnea, ObstructiveMajor depressive disorderObstructive sleep apneaSuicideTreatment-resistance

Identifiers

PMID31238203
PMCPMC6606377

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.