Evidence map›Paper›PMID 31238174›Full record

ReviewAgeing research reviews2019

"All is not lost"-Rethinking the nature of memory and the self in dementia.

Cherie Strikwerda-Brown, Matthew D Grilli, Jessica Andrews-Hanna, Muireann Irish

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Ageing research reviews, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed.

  1. Article
  2. The properties of personal semantics.Memory & cognition · 2026
    Article
  3. Review
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  5. Review
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  7. Article
  8. Making Sense of Dementia: Older Adults' Subjective Representations of Dementia and Alzheimer's Disease.The journals of gerontology. Series B, Psychological sciences and social sciences · 2024
    Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
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  15. Article
  16. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Cherie Strikwerda-BrownThe University of Sydney, Brain and Mind Centre, Camperdown, New South Wales, Australia; The University of Sydney, School of Psychology, Camperdown, New South Wales, Australia; Australian Research Council Centre of Excellence in Cognition and its Disorders, Sydney, New South Wales, Australia.
Matthew D GrilliDepartment of Psychology, University of Arizona, Tucson, AZ, USA; Evelyn F. McKnight Brain Institute, University of Arizona, Tucson, AZ, USA; Department of Neurology, University of Arizona, Tucson, AZ, USA.
Jessica Andrews-HannaDepartment of Psychology, University of Arizona, Tucson, AZ, USA; Evelyn F. McKnight Brain Institute, University of Arizona, Tucson, AZ, USA; Cognitive Science, University of Arizona, Tucson, AZ, USA.
Muireann IrishThe University of Sydney, Brain and Mind Centre, Camperdown, New South Wales, Australia; The University of Sydney, School of Psychology, Camperdown, New South Wales, Australia; Australian Research Council Centre of Excellence in Cognition and its Disorders, Sydney, New South Wales, Australia. Electronic address: muireann.irish@sydney.edu.au.

Funding

Research Education ComponentP30AG019610 · NIA · SUN HEALTH RESEARCH INSTITUTE · PI GONZALEZ HERNANDEZ, GRACIELA · 2001 to 2020
$32.5M
NIA NIH HHS P30 AG019610
6 · The paper itself

Abstract

Memory and the self have long been considered intertwined, leading to the assumption that without memory, there can be no self. This line of reasoning has led to the misconception that a loss of memory in dementia necessarily results in a diminished sense of self. Here, we challenge this assumption by considering discrete facets of self-referential memory, and their relative profiles of loss and sparing, across three neurodegenerative disorders: Alzheimer's disease, semantic dementia, and frontotemporal dementia. By exploring canonical expressions of the self across past, present, and future contexts in dementia, relative to healthy ageing, we reconcile previous accounts of loss of self in dementia, and propose a new framework for understanding and managing everyday functioning and behaviour. Notably, our approach highlights the multifaceted and dynamic nature in which the temporally-extended self is likely to change in healthy and pathological ageing, with important ramifications for development of person-centred care. Collectively, we aim to promote a cohesive sense of self in dementia across past, present, and future contexts, by demonstrating how, ultimately, 'All is not lost'.

Indexed as

MemoryAlzheimer DiseaseFrontotemporal DementiaHumansAlzheimer’s diseaseAutobiographical memoryFrontotemporal dementiaFuture thinkingPersonal semanticsSemantic dementia

Identifiers

PMID31238174
PMCPMC6726574

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.