Evidence map›Paper›PMID 31238067›Full record

ArticleEuropean journal of pharmacology2019

All-trans retinoic acid attenuates isoproterenol-induced cardiac dysfunction through Crabp1 to dampen CaMKII activation.

Sung Wook Park, Jennifer Nhieu, Yi-Wei Lin, Li-Na Wei

Open access · greenAbstract read
In one paragraph

Article in European journal of pharmacology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 25 citations in OpenAlex.

  1. Retinoic acid in health and disease.Signal transduction and targeted therapy · 2026
    Review
  2. Article
  3. Retinoic acid signaling and metabolism in heart failure.American journal of physiology. Heart and circulatory physiology · 2025
    Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Role of cellular retinol-binding protein, type 1 and retinoid homeostasis in the adult mouse heart: A multi-omic approach.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2022
    Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Research progress on the role of CaMKII in heart disease.American journal of translational research · 2020
    Review
  18. All-International journal of molecular sciences · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Sung Wook ParkDepartment of Pharmacology University of Minnesota, Minneapolis, MN, 55455, USA.
Jennifer NhieuDepartment of Pharmacology University of Minnesota, Minneapolis, MN, 55455, USA.
Yi-Wei LinDepartment of Pharmacology University of Minnesota, Minneapolis, MN, 55455, USA.
Li-Na WeiDepartment of Pharmacology University of Minnesota, Minneapolis, MN, 55455, USA. Electronic address: weixx009@umn.edu.
University of Minnesota · US

Funding

Studies of nuclear receptor corepressor, NRIP1, in vitamin A signaling pathwaysR01DK060521 · NIDDK · UNIVERSITY OF MINNESOTA TWIN CITIES · PI WEI, LI-NA · 2002 to 2022
$6.9M
TR2 NUCLEAR RECEPTOR IN VITAMIN A SIGNALING PATHWAYSR01DK054733 · NIDDK · UNIVERSITY OF MINNESOTA TWIN CITIES · PI WEI, LI-NA · 1999 to 2021
$5.7M
NIDDK NIH HHS R01 DK054733NIDDK NIH HHS R01 DK060521
6 · The paper itself

Abstract

Inhibiting Ca

Indexed as

AnimalsCalcium-Calmodulin-Dependent Protein Kinase Type 2Catalytic DomainEnzyme ActivationHeartIsoproterenolMicePhosphorylationReceptors, Retinoic AcidCalcium-Calmodulin-Dependent Protein Kinase Type 2IsoproterenolReceptors, Retinoic Acidretinoic acid binding protein I, cellularCaMKIICardiac remodelingCrabp1Retinoic acid

Identifiers

PMID31238067
PMCPMC6667285
OpenAlexW2951546497

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.