Evidence map›Paper›PMID 31238043›Full record

ReviewJournal of molecular biology2020

Mechanistic Insights into the Role of Atg11 in Selective Autophagy.

Katarzyna Zientara-Rytter, Suresh Subramani

Open access · greenAbstract readReview
In one paragraph

Review in Journal of molecular biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed
5.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 78 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Katarzyna Zientara-RytterSection of Molecular Biology, Division of Biological Sciences, University of California San Diego, La Jolla, CA 92093, USA. Electronic address: kzientararytter@ucsd.edu.
Suresh SubramaniSection of Molecular Biology, Division of Biological Sciences, University of California San Diego, La Jolla, CA 92093, USA.
University of California, San Diego · US

Funding

TARGETING OF PROTEINS INTO PEROXISOMESR01DK041737 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI AITCHISON, JOHN D., SUBRAMANI, SURESH · 1990 to 2025
$8.4M
Developing AIM/LIR-independent fluorescent protein sensors for mAtg8sR03AI142388 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SUBRAMANI, SURESH · 2019 to 2020
$157k
NIAID NIH HHS R03 AI142388NIDDK NIH HHS R01 DK041737
6 · The paper itself

Abstract

Macroautophagy (referred to hereafter as autophagy) is an intracellular degradation pathway in which the formation of a double-membrane vesicle called the autophagosome is a key event in the transport of multiple cytoplasmic cargo (e.g., proteins, protein aggregates, lipid droplets or organelles) to the vacuole (lysosome in mammals) for degradation and recycling. During this process, autophagosomes are formed de novo by membrane fusion events leading to phagophore formation initiated at the phagophore assembly site. In yeast, Atg11 and Atg17 function as protein scaffolds, essential for selective and non-selective types of autophagy, respectively. While Atg17 functions in non-selective autophagy are well-defined in the literature, less attention is concentrated on recent findings regarding the roles of Atg11 in selective autophagy. Here, we summarize current knowledge about the Atg11 scaffold protein and review recent findings in the context of its role in selective autophagy initiation and autophagosome formation.

Indexed as

AutophagyAnimalsAutophagosomesAutophagy-Related ProteinsHumansMacroautophagyProtein Interaction MapsSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsVesicular Transport ProteinsAtg11 protein, S cerevisiaeAtg17 protein, S cerevisiaeAutophagy-Related ProteinsSaccharomyces cerevisiae ProteinsVesicular Transport ProteinsAtg11Atg17autophagosomemembrane tetheringscaffold protein

Identifiers

PMID31238043
PMCPMC6925662
OpenAlexW2952510256

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.