ArticleInternational journal of epidemiology2019
Maternal pre-pregnancy obesity and timing of puberty in sons and daughters: a population-based cohort study.
Article in International journal of epidemiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.
- Pubertal timing in boys and girls born to mothers with gestational diabetes mellitus: a systematic review.European journal of endocrinology · 2021Pooled it
- Early-life programming of hypothalamic circuits by maternal obesity: implications for neuroendocrine disorders.Reviews in endocrine & metabolic disorders · 2026Review
- Maternal pre-pregnancy overweight/obesity, in-utero exposure to toxic heavy metals, and offspring age at peak height velocity: A prospective birth cohort study.Environmental research · 2025Article
- Maternal time interval between menarche and childbirth is associated with daughter's age at menarche.Acta obstetricia et gynecologica Scandinavica · 2025Article
- Intergenerational transitions in age at menarche: insights from Chandauli district, Uttar Pradesh, India.BMC women's health · 2025Article
- The role of adipose tissue in puberty and reproductive health.Frontiers in endocrinology · 2025Review
- Maternal pre-pregnancy BMI and reproductive health in adult sons: a study in the Danish National Birth Cohort.Human reproduction (Oxford, England) · 2024Article
- Small for gestational age and age at menarche in a contemporary population-based U.S. sample.PloS one · 2024Article
- The effect of environmental factors on precocious puberty in children: a case-control study.BMC pediatrics · 2023Article
- Maternal and prenatal factors and age at thelarche in the LEGACY Girls Study cohort: implications for breast cancer risk.International journal of epidemiology · 2023Article
- Effects of Elevated Maternal Adiposity on Offspring Reproductive Health: A Perspective From Epidemiologic Studies.Journal of the Endocrine Society · 2022Review
- Prenatal programming of developmental trajectories for obesity risk and early pubertal timing.Developmental psychology · 2022Article
- Palmitic Acid Impedes Extravillous Trophoblast Activity by Increasing MRP1 Expression and Function.Biomolecules · 2022Article
- Early programming of reproductive health and fertility: novel neuroendocrine mechanisms and implications in reproductive medicine.Human reproduction update · 2022Review
- Use of Agriculturally Important Animals as Models in Biomedical Research.Advances in experimental medicine and biology · 2022Review
- Association of mode of delivery with offspring pubertal development in Project Viva: a prospective pre-birth cohort study in the USA.Human reproduction (Oxford, England) · 2021Article
- Comparing adolescent self staging of pubertal development with hormone biomarkers.Journal of pediatric endocrinology & metabolism : JPEM · 2021Article
- Prevalence of precocious puberty among Chinese children: a school population-based study.Endocrine · 2021Article
- Pregnancy Weight Gain as a Predictor of Fetal Wellbeing in Liver Transplant Recipients.Annals of transplantation · 2020Article
- Parental Obesity and Offspring Pubertal Development: Project Viva.The Journal of pediatrics · 2019Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIn many countries, an increased prevalence of obesity in pregnancy has coincided with a declining pubertal age. We aimed to explore the potential effect of maternal pre-pregnancy overweight and obesity on timing of puberty in sons and daughters.
methodsBetween 2012 and 2018, 15 819 of 22 439 invited children from the Danish National Birth Cohort, born 2000-03, provided half-yearly information from the age of 11 years on the pubertal milestones: Tanner stages, voice break, first ejaculation, menarche, acne and axillary hair. We estimated adjusted mean monthly differences (with 95% confidence intervals) in age at attaining the pubertal milestones for children exposed to maternal pre-pregnancy obesity [body mass index (BMI) ≥30.0 kg/m2] or overweight (BMI 25.0 to 29.9 kg/m2) with normal weight (BMI 18.5 to 24.9 kg/m2) as reference. In mediation analysis, we explored whether childhood BMI at age 7 years mediated the associations.
resultsMaternal pre-pregnancy obesity was associated with earlier age at attaining most pubertal milestones in sons, and pre-pregnancy overweight and obesity were associated with earlier age at attaining all pubertal milestones in daughters. When combining all pubertal milestones, pre-pregnancy obesity [sons: -1.5 (-2.5, -0.4) months; daughters: -3.2 (-4.2, -2.1) months] and overweight [daughters only: -2.6 (-3.3, -1.8) months] were associated with earlier timing of puberty. The associations in sons were completely mediated by higher childhood BMI and partly so in daughters.
conclusionsMaternal pre-pregnancy obesity appears to lower timing of puberty through childhood obesity in sons and mainly through other mechanisms in daughters.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.