ArticlePloS one2019
Increased ischemic stroke risk in patients with Behçet's disease: A nationwide population-based cohort study.
Article in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.
- Prevalence of antiphospholipid antibodies in Behçet's disease: A systematic review and meta-analysis.PloS one · 2020Pooled it
- Stroke in autoimmune rheumatic diseases.Rheumatology international · 2026Review
- Behçet's disease unraveled: Insights into clinical manifestations, diagnosis, and management.Medicine · 2025Review
- Behçet's disease: recurrent ischemic stroke as an initial presentation - a case based review.The Journal of international medical research · 2025Review
- Stroke frequency, associated factors, and clinical features in primary systemic vasculitis: a multicentric observational study.Journal of neurology · 2024Observational
- Evaluating the risk of ischemic stroke at a young age in patients with autoimmune inflammatory rheumatic diseases: a population-based cohort study in Taiwan.Frontiers in immunology · 2024Article
- Behçet's disease in Wales: an epidemiological description of national surveillance data.Orphanet journal of rare diseases · 2022Article
- Article
- Uveitis as a potential predictor of acute myocardial infarction in patients with Behcet's disease: a population-based cohort study.BMJ open · 2021Article
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBehçet's disease (BD) is a recurrent, multisystemic, inflammatory disorder that mainly affects blood vessels. Because recurrent inflammation of blood vessels in the brain plays a crucial role in the development of ischemic stroke, we hypothesized that patients with BD might have an elevated risk of ischemic stroke. This potential association has been suggested in a few case reports, but not epidemiological studies. Hence, the present study aimed to examine the relation between BD and subsequent ischemic stroke in Taiwan using a nationwide, population-based database.
methodsTo establish a study cohort, the longitudinal data of 306 patients newly diagnosed with BD during 2000-2010 were extracted from the National Health Insurance Research Database, Taiwan. For comparison of ischemic stroke incidence, a control cohort of 1224 subjects without BD was established using a frequency-matched ratio of 1:4 for age, sex, and pre-existing comorbidities.
resultsDuring the 10-year follow-up, 13 (4.2%) patients with BD and 20 (1.6%) control subjects experienced ischemic stroke. Kaplan-Meier analysis revealed the higher prevalence of ischemic stroke in the BD group (log-rank test, p = 0.001). After adjusting for comorbidities and demographic characteristics, Cox regression analysis revealed that patients with BD had a 2.77-fold risk of ischemic stroke (95% confidence interval, 1.38-5.57) compared to control subjects.
conclusionsPatients with BD have an elevated risk of ischemic stroke. Hence, BD may affect the vascular system in the brain, resulting in a stroke event.
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