ArticleMultiple sclerosis (Houndmills, Basingstoke, England)2020
Multiple sclerosis relapse risk in the postoperative period: Effects of invasive surgery and anesthesia.
Article in Multiple sclerosis (Houndmills, Basingstoke, England), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed, 11 citations in OpenAlex.
- Acute neurological deficit following lumbar microdiscectomy: a multiple sclerosis relapse mimicking a surgical complication - a case report and literature review.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026Article
- Characteristics of Disease Relapses and Their Relationships with Weather Conditions in Patients with Multiple Sclerosis.Journal of clinical medicine · 2025Article
- Evaluating the impact of multiple sclerosis on 2 year postoperative outcomes following long fusion for adult spinal deformity: a propensity score-matched analysis.Spine deformity · 2025Article
- Impact of surgery in patients with multiple sclerosis: a nationwide cohort study.Frontiers in neurology · 2025Article
- Article
- Iranian specialists' approach to surgery in patients with multiple sclerosis.Current journal of neurology · 2023Article
- Outcomes of Laparoscopic One-Anastomosis Gastric Bypass (OAGB) in Patients with Morbid Obesity and Multiple Sclerosis.Obesity surgery · 2021Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundPostoperative multiple sclerosis (MS) relapses are a concern among patients and providers.
objectiveTo determine whether MS relapse risk is higher postoperatively.
methodsData were extracted from medical records of MS patients undergoing surgery at a tertiary center (2000-2016). Conditional logistic regression estimated within-patient unadjusted and age-adjusted odds of postoperative versus preoperative relapse.
resultsAmong 281 patients and 609 surgeries, 12 postoperative relapses were identified. The odds of postoperative versus preoperative relapse in unadjusted (odds ratio (OR) = 0.56, 95% confidence interval (CI) = 0.18-1.79;
conclusionsSurgery/anesthesia exposure did not increase postoperative relapse risk. These findings require confirmation in larger studies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.