Evidence map›Paper›PMID 31237564›Full record

ArticleeLife2019

tRNA ligase structure reveals kinetic competition between non-conventional mRNA splicing and mRNA decay.

Jirka Peschek, Peter Walter

Open access · goldAbstract read
In one paragraph

Article in eLife, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
2.0field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 36 citations in OpenAlex.

  1. Enzymology of the metazoan tRNA ligase complex: a lifetime in cycles.Cellular and molecular life sciences : CMLS · 2026
    Review
  2. Article
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  12. Fungi of the order Mucorales express a "sealing-only" tRNA ligase.bioRxiv : the preprint server for biology · 2023
    Article
  13. Review
  14. The life and times of a tRNA.RNA (New York, N.Y.) · 2023
    Review
  15. Article
  16. Review
  17. Article
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  19. Article
  20. Vps34 and TOR Kinases CoordinateMolecular and cellular biology · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Jirka PeschekDepartment of Biochemistry and Biophysics, Howard Hughes Medical Institute, University of California, San Francisco, San Francisco, United States.ORCID 0000-0001-8158-9301
Peter WalterDepartment of Biochemistry and Biophysics, Howard Hughes Medical Institute, University of California, San Francisco, San Francisco, United States.ORCID 0000-0002-6849-708X
Howard Hughes Medical Institute · US

Funding

MECHANISM OF PROTEIN TRANSLOCATION ACROSS MEMBRANESR01GM032384 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI STROUD, ROBERT M · 1985 to 2023
$7.6M
MECHANISM OF PROTEIN TRANSLOCATION ACROSS MEMBRANESR37GM032384 · NIGMS · UNIVERSITY OF CALIFORNIA SAN FRANCISCO · PI WALTER, PETER · 1993 to 2002
$907k
Howard Hughes Medical Institute HHMI826735-0012Human Frontier Science Program Postdoctoral FellowshipNIGMS NIH HHS R01 GM032384NIGMS NIH HHS R01, GM032384NIGMS NIH HHS R37 GM032384
6 · The paper itself

Abstract

Yeast tRNA ligase (Trl1) is an essential trifunctional enzyme that catalyzes exon-exon ligation during tRNA biogenesis and the non-conventional splicing of

Indexed as

Basic-Leucine Zipper Transcription FactorsChaetomiumCrystallography, X-RayEndoplasmic ReticulumEndoplasmic Reticulum StressGene Expression Regulation, FungalKineticsPhosphoric Diester HydrolasesPolynucleotide 5'-Hydroxyl-KinasePolynucleotide LigasesProtein ConformationProtein FoldingProtein Serine-Threonine KinasesRNA SplicingRNA StabilityUnfolded Protein ResponseBasic-Leucine Zipper Transcription FactorsPhosphoric Diester HydrolasesPolynucleotide 5'-Hydroxyl-KinasePolynucleotide LigasesProtein Serine-Threonine KinasestRNA ligase, yeastbiochemistrychemical biologymolecular biophysicsmRNA quality controlno-go decayRNA ligaseRNA processingS. cerevisiaestructural biologytRNA splicingunfolded protein response

Identifiers

PMID31237564
PMCPMC6592678
OpenAlexW2953742709

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.