ReviewGlia2019
The role of sleep and wakefulness in myelin plasticity.
Review in Glia, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
49 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Effectiveness of combined versus single circadian interventions in neonatal and pediatric intensive care units: a systematic review with meta-analysis.Frontiers in neurologyPooled it
- Adaptive conduction delays and phase locking in spiking Haken Lighthouse networks.Biological cybernetics · 2026Article
- Beyond the Wiring: White Matter as a Dynamic Regulator of Brain Function and Disease.Neuroscience bulletin · 2026Review
- A circadian clock gene homolog regulates developmental timing and male mating circuitry iniScience · 2026Article
- Chronic exposure to LED lighting impairs prefrontal cortex-dependent cognitive functions in adolescent rats.Scientific reports · 2026Article
- Joint effects of sleep behaviors and physical activity on brain structure and cognitive function.Fundamental research · 2026Article
- Cell-specific effects of acute sleep deprivation on transcriptomic signatures of non-neuronal cells in the mouse hippocampus and prefrontal cortex.bioRxiv : the preprint server for biology · 2026Article
- Sleep loss induces cholesterol-associated myelin dysfunction.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Longitudinal associations of rest-activity rhythms with executive function, plasma biomarkers, and clinical outcomes in older adults.Frontiers in aging neuroscience · 2026Article
- Demyelination and Cognitive Performance in Long COVID Patients with Insomnia and/or Depression.International journal of molecular sciences · 2025Article
- Sleep Health and White Matter Integrity in the UK Biobank.Journal of sleep research · 2025Article
- Early life adversity and adult attention-deficit/hyperactivity disorder (ADHD): Pathways to persistence and adult susceptibility.Neuroscience and biobehavioral reviews · 2025Review
- Sleep Disturbances Associated With Hidden Hearing Loss: Insights From Human Data and a Mouse Model of Sleep Fragmentation.Brain and behavior · 2025Observational
- Associations between sleep problems, cortical morphometry, and structural brain network organization in preschool children with autism: a retrospective observational study.European journal of pediatrics · 2025Observational
- NKCC1 inhibition improves sleep quality and EEG information content in a Down syndrome mouse model.iScience · 2025Article
- Insomnia, early and late rising are associated with small hippocampal volume and large white matter hyperintensity burden.Alzheimer's research & therapy · 2025Article
- White matter microstructure statistically mediates associations between circadian rest/activity rhythms and cognition in older adults.Sleep advances : a journal of the Sleep Research Society · 2025Article
- Plasticity of Myelination.Advances in neurobiology · 2025Review
- Characteristics and correlations of sleep disorders in patients with relapsing-remitting multiple sclerosis in China: a cross-sectional study.Frontiers in neurology · 2025Article
- Myelin Changes in Poor Sleepers: Insights into Glymphatic Clearance Function and Regional Circadian Clock Gene Expression.Aging and disease · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Myelin plasticity is gaining increasing recognition as an essential partner to synaptic plasticity, which mediates experience-dependent brain structure and function. However, how neural activity induces adaptive myelination and which mechanisms are involved remain open questions. More than two decades of transcriptomic studies in rodents have revealed that hundreds of brain transcripts change their expression in relation to the sleep-wake cycle. These studies consistently report upregulation of myelin-related genes during sleep, suggesting that sleep represents a window of opportunity during which myelination occurs. In this review, we summarize recent molecular and morphological studies detailing the dependence of myelin dynamics after sleep, wake, and chronic sleep loss, a condition that can affect myelin substantially. We present novel data about the effects of sleep loss on the node of Ranvier length and provide a hypothetical mechanism through which myelin changes in response to sleep loss. Finally, we discuss the current findings in humans, which appear to confirm the important role of sleep in promoting white matter integrity.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.