Evidence map›Paper›PMID 31237235›Full record

ArticleeLife2019

Haplotypes spanning centromeric regions reveal persistence of large blocks of archaic DNA.

Sasha A Langley, Karen H Miga, Gary H Karpen, Charles H Langley

Abstract read
In one paragraph

Article in eLife, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Neural posterior estimation for population genetics.bioRxiv : the preprint server for biology · 2026
    Article
  5. Polymorphic 3D genome architecture mediated by transposable elements.bioRxiv : the preprint server for biology · 2026
    Article
  6. Article
  7. Article
  8. Non-canonical DNA in human and other ape telomere-to-telomere genomes.bioRxiv : the preprint server for biology · 2025
    Article
  9. Article
  10. From complete genomes to pangenomes.American journal of human genetics · 2024
    Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Defining a core configuration for human centromeres during mitosis.bioRxiv : the preprint server for biology · 2023
    Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Sasha A LangleyDepartment of Molecular and Cell Biology, University of California, Berkeley, Berkeley, United States.ORCID 0000-0002-5138-7394
Karen H MigaUC Santa Cruz Genomics Institute, University of California, Santa Cruz, Santa Cruz, United States.ORCID 0000-0002-3670-4507
Gary H KarpenDepartment of Molecular and Cell Biology, University of California, Berkeley, Berkeley, United States.ORCID 0000-0003-1534-0385
Charles H LangleyDepartment of Evolution and Ecology, University of California, Davis, Davis, United States.ORCID 0000-0001-6160-5503

Funding

Organization and Function of the Heterochromatin Holodomain and SubdomainsR01GM117420 · NIGMS · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI KARPEN, GARY H · 2016 to 2019
$2.5M
Regulation of Centromere Protein Stability and Impact on Cancer ProgressionR01GM119011 · NIGMS · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI KARPEN, GARY H · 2016 to 2019
$2.1M
NIGMS NIH HHS R01 GM117420NIGMS NIH HHS R01 GM119011
6 · The paper itself

Abstract

Despite critical roles in chromosome segregation and disease, the repetitive structure and vast size of centromeres and their surrounding heterochromatic regions impede studies of genomic variation. Here we report the identification of large-scale haplotypes (

Indexed as

CentromereChromosomes, HumanGenetic VariationHaplotypesDNA, SatelliteHumansRepetitive Sequences, Nucleic AcidDNA, Satellite1000 Genomescentromereevolutionary biologygeneticsgenomicshaplotypeheterochromatinhumanNeanderthalsatellite DNA

Identifiers

PMID31237235
PMCPMC6592686

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.