Evidence map›Paper›PMID 31237134›Full record

Trial reportDiabetes & metabolism journal2020

Efficacy and Safety of Omega-3 Fatty Acids in Patients Treated with Statins for Residual Hypertriglyceridemia: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial.

Ji Eun Jun, In Kyung Jeong, Jae Myung Yu, Sung Rae Kim, In Kye Lee, Kyung Ah Han, Sung Hee Choi, Soo Kyung Kim, Hyeong Kyu Park, Ji Oh Mok and 20 more

Open access · goldAbstract readClinical Trial, Phase IIIMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Diabetes & metabolism journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 2 pooled it
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 2 syntheses or guidelines pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Trial
  5. Article
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

30 authors at 20 institutions in 2 countries.

Ji Eun Jun *Department of Endocrinology and Metabolism, Kyung Hee University Hospital at Gangdong, Kyung Hee University School of Medicine, Seoul, Korea.ORCID 0000-0002-7204-4913
In Kyung Jeong *Department of Endocrinology and Metabolism, Kyung Hee University Hospital at Gangdong, Kyung Hee University School of Medicine, Seoul, Korea.ORCID 0000-0001-7857-546X
Jae Myung YuDivision of Endocrinology and Metabolism, Department of Internal Medicine, Hallym University Kangnam Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Korea.
Sung Rae KimDivision of Endocrinology and Metabolism, Department of Internal Medicine, Bucheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Bucheon, Korea.
In Kye LeeDepartment of Endocrinology and Metabolism of Internal Medicine, Kyungpook National University Hospital, School of Medicine, Kyungpook National University, Daegu, Korea.
Kyung Ah HanDivision of Endocrinology and Metabolism, Department of Internal Medicine, Nowon Eulji Medical Center, Eulji University School of Medicine, Seoul, Korea.
Sung Hee ChoiDivision of Endocrinology and Metabolism, Department of Internal Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea.
Soo Kyung KimDivision of Endocrinology and Metabolism, Department of Internal Medicine, CHA Bundang Medical Center, CHA University School of Medicine, Seongnam, Korea.
Hyeong Kyu ParkDivision of Endocrinology and Metabolism, Department of Internal Medicine, Soonchunhyang University Seoul Hospital, Soonchunhyang University College of Medicine, Seoul, Korea.
Ji Oh MokDivision of Endocrinology and Metabolism, Department of Internal Medicine, Soonchunhyang University Bucheon Hospital, Soonchunhyang University College of Medicine, Bucheon, Korea.
Yong Ho LeeDivision of Endocrinology and Metabolism, Department of Internal Medicine, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
Hyuk Sang KwonDivision of Endocrinology and Metabolism, Department of Internal Medicine, Yeouido St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
So Hun KimDivision of Endocrinology and Metabolism Department of Internal Medicine, Inha University Hospital, Inha University School of Medicine, Incheon, Korea.
Ho Cheol KangDivision of Endocrinology and Metabolism, Department of Internal Medicine, Chonnam National University Hwasun Hospital, Chonnam National University Medical School, Hwasun, Korea.
Sang Ah LeeDivision of Endocrinology and Metabolism, Department of Internal Medicine, Jeju National University School of Medicine, Jeju, Korea.
Chang Beom LeeDepartment of Endocrinology and Metabolism, Hanyang University Guri Hospital, Hanyang University College of Medicine, Guri, Korea.
Kyung Mook ChoiDivision of Endocrinology and Metabolism, Department of Internal Medicine, Korea University Guro Hospital, Korea University College of Medicine, Seoul, Korea.
Sung Ho HerDivision of Cardiology, Department of Internal Medicine, Daejeon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Daejeon, Korea.
Won Yong ShinDivision of Cardiology, Department of Internal Medicine, Soonchunhyang University Cheonan Hospital, Soonchunhyang University College of Medicine, Cheonan, Korea.
Mi Seung ShinDivision of Cardiology, Department of Internal Medicine, Gachon University Gil Medical Center, Gachon University College of Medicine, Incheon, Korea.
Hyo Suk AhnDivision of Cardiology, Department of Internal Medicine, Uijeongbu St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Uijeongbu, Korea.
Seung Ho KangDivision of Cardiology, Department of Internal Medicine, Cheju Halla General Hospital, Jeju, Korea.
Jin Man ChoDivision of Cardiology, Department of Internal Medicine, Kyung Hee University Hospital at Gangdong, Kyung Hee University School of Medicine, Seoul, Korea.
Sang Ho JoDivision of Cardiology, Department of Internal Medicine, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang, Korea.
Tae Joon ChaDivision of Cardiology, Department of Internal Medicine, Kosin University Gospel Hospital, Kosin University College of Medicine, Busan, Korea.
Seok Yeon KimDivision of Cardiology, Department of Internal Medicine, Seoul Medical Center, Seoul, Korea.
Kyung Heon WonDivision of Cardiology, Department of Internal Medicine, Seoul Medical Center, Seoul, Korea.
Dong Bin KimDivision of Cardiology, Department of Internal Medicine, St. Paul's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Jae Hyuk LeeDivision of Endocrinology, Department of Internal Medicine, Myongji Hospital, Goyang, Korea.
Moon Kyu LeeDivision of Endocrinology and Metabolism, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. leemk@skku.edu.ORCID 0000-0002-8728-7184
Seoul Medical Center · KRKyung Hee University Hospital at Gangdong · KRSoonchunhyang University · KRCheju Halla General Hospital · KRChonnam National University Hwasun Hospital · KREulji University · KRGachon University Gil Medical Center · KRHallym University Kangnam Sacred Heart Hospital · KRHallym University Sacred Heart Hospital · KRHanyang University Guri Hospital · KRJeju National University · KRKorea University · KRKosin University Gospel Hospital · KRKyungpook National University Hospital · KRMyongji Hospital · KRSamsung Medical Center · KRSeoul National University Bundang Hospital · KRSoonchunhyang University Hospital Seoul · KRSt. Paul's Hospital · KRThe Catholic University of Korea Daejeon St. Mary's Hospital · KR

Funding

Kuhnil Pharmaceutical Co., Ltd.
6 · The paper itself

Abstract

backgroundCardiovascular risk remains increased despite optimal low density lipoprotein cholesterol (LDL-C) level induced by intensive statin therapy. Therefore, recent guidelines recommend non-high density lipoprotein cholesterol (non-HDL-C) as a secondary target for preventing cardiovascular events. The aim of this study was to assess the efficacy and tolerability of omega-3 fatty acids (OM3-FAs) in combination with atorvastatin compared to atorvastatin alone in patients with mixed dyslipidemia.

methodsThis randomized, double-blind, placebo-controlled, parallel-group, and phase III multicenter study included adults with fasting triglyceride (TG) levels ≥200 and <500 mg/dL and LDL-C levels <110 mg/dL. Eligible subjects were randomized to ATOMEGA (OM3-FAs 4,000 mg plus atorvastatin calcium 20 mg) or atorvastatin 20 mg plus placebo groups. The primary efficacy endpoints were the percent changes in TG and non-HDL-C levels from baseline at the end of treatment.

resultsAfter 8 weeks of treatment, the percent changes from baseline in TG (-29.8% vs. 3.6%,

conclusionThe addition of OM3-FAs to atorvastatin improved TG and non-HDL-C levels to a significant extent compared to atorvastatin alone in subjects with residual hypertriglyceridemia.

Indexed as

AgedAtorvastatinCholesterol, HDLCholesterol, LDLDouble-Blind MethodFatty Acids, Omega-3FemaleHumansHydroxymethylglutaryl-CoA Reductase InhibitorsHypertriglyceridemiaLinear ModelsMaleMiddle AgedTriglyceridesAtorvastatinCholesterol, HDLCholesterol, LDLFatty Acids, Omega-3Hydroxymethylglutaryl-CoA Reductase InhibitorsTriglyceridesAtorvastatinFatty acids, omega-3Hypertriglyceridemia

Identifiers

PMID31237134
PMCPMC7043989
OpenAlexW2951092959

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.