ArticleHigh blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension2019
Is the Oral Microbiome Associated with Blood Pressure in Older Women?
Article in High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 37 citations in OpenAlex.
- A comparative analysis of oral microbial communities in hypertensive patients with and without chronic periodontitis.BMC oral health · 2026Article
- Unraveling the oral microbiome's role in Alzheimer's disease: From pathophysiology to therapeutic potential.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Review
- Article
- Oral microbiome alpha diversity and all-cause, cardiovascular, and non-cardiovascular mortality in US adults: Evidence from the NHANES 2009-2019.Atherosclerosis · 2025Observational
- Connection between oral health and chronic diseases.MedComm · 2025Review
- Gut and oral microbiome profiles in patients with obesity and ischemic heart disease.Frontiers in cellular and infection microbiology · 2025Article
- Investigation of oral microbiome composition in elderly Chinese patients with hypertension: a cross-sectional study.Journal of oral microbiology · 2025Article
- The Oral Microbiome in Diabetes, Arterial Hypertension, and Obesity: A Scoping Review.Advances in experimental medicine and biology · 2025Article
- The association between the oral microbiome and hypertension: a systematic review.Journal of oral microbiology · 2025Article
- Current clinical framework on nitric oxide role in periodontal disease and blood pressure.Clinical oral investigations · 2024Review
- Defining Porphyromonas gingivalis strains associated with periodontal disease.Scientific reports · 2024Article
- Altered oral microbiome in Sudanese Toombak smokeless tobacco users carries a newly emerging risk of squamous cell carcinoma development and progression.Scientific reports · 2023Article
- Roles of oral microbiota and oral-gut microbial transmission in hypertension.Journal of advanced research · 2023Article
- The role of the oral microbiome in smoking-related cardiovascular risk: a review of the literature exploring mechanisms and pathways.Journal of translational medicine · 2022Review
- Salivary microbiome in chronic kidney disease: what is its connection to diabetes, hypertension, and immunity?Journal of translational medicine · 2022Article
- [Latest Research Findings on the Mechanism of Periodontal Pathogens in Cardiovascular Disease].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2022Review
- Oral Microbiome Is Associated With Incident Hypertension Among Postmenopausal Women.Journal of the American Heart Association · 2022Article
- Periodontitis, Blood Pressure, and the Risk and Control of Arterial Hypertension: Epidemiological, Clinical, and Pathophysiological Aspects-Review of the Literature and Clinical Trials.Current hypertension reports · 2021Review
- Dysbiosis of the Salivary Microbiome is Associated with Hypertension and Correlated with Metabolic Syndrome Biomarkers.Diabetes, metabolic syndrome and obesity : targets and therapy · 2021Article
- Severe preeclampsia is associated with a higher relative abundance of Prevotella bivia in the vaginal microbiota.Scientific reports · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 2 institutions in 1 country.
Funding
Abstract
introductionA possible role of the oral microbiome, specifically oral nitrate reducing flora, in blood pressure (BP) homeostasis, if proven etiologic in nature, could lead to novel mechanism-based therapy to improve hypertension prevention and control.
aimThis cross-sectional study characterized and compared the oral microbiome between four study groups based on BP status among 446 postmenopausal women aged 53-82 years.
methodsThree study groups were not taking hypertension medication and were separated based on BP, as follows: normal BP (systolic < 120 and diastolic < 80; N = 179), elevated BP/Stage I hypertension (systolic 120-139 or diastolic 80-90; N = 106), Stage II hypertension (systolic > 140 or diastolic > 90; N = 42). The forth group consisted of anyone taking hypertension medications, regardless of BP (N = 119). Subgingival microbiome composition was determined using 16S rRNA sequencing with the Illumina MiSeq platform. Kruskal-Wallis tests were used to compare species-level relative abundance of bacterial operational taxonomic units across the four groups.
resultsSixty-five bacterial species demonstrated significant differences in relative abundance in women with elevated BP or using hypertension medication as compared to those with normal BP. After correction for multiple testing, two species, Prevotella oral (species 317) and Streptococcus oralis, remained significant and were lower in abundance among women taking antihypertension medications compared to those with normal BP (corrected P < 0.05).
conclusionsThese data provide novel description of oral subgingival bacteria grouped according to BP status. Additional larger studies including functional analysis and prospective designs will help further assess the potential role of the oral microbiome in BP regulation and hypertension.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.