Evidence map›Paper›PMID 31236791›Full record

ArticleAnnals of biomedical engineering2019

Analysis of Inlet Velocity Profiles in Numerical Assessment of Fontan Hemodynamics.

Zhenglun Alan Wei, Connor Huddleston, Phillip M Trusty, Shelly Singh-Gryzbon, Mark A Fogel, Alessandro Veneziani, Ajit P Yoganathan

Open access · greenAbstract read
In one paragraph

Article in Annals of biomedical engineering, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 35 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Zhenglun Alan WeiWallace H. Coulter School of Biomedical Engineering, Georgia Institute of Technology, 387 Technology Circle, Suite 232, Atlanta, GA, 30313-2412, USA.
Connor HuddlestonSchool of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, GA, USA.
Phillip M TrustyWallace H. Coulter School of Biomedical Engineering, Georgia Institute of Technology, 387 Technology Circle, Suite 232, Atlanta, GA, 30313-2412, USA.
Shelly Singh-GryzbonWallace H. Coulter School of Biomedical Engineering, Georgia Institute of Technology, 387 Technology Circle, Suite 232, Atlanta, GA, 30313-2412, USA.
Mark A FogelDepartment of Cardiology, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Alessandro VenezianiDepartment of Mathematics, Department of Computer Science, Emory University, Atlanta, GA, USA.
Ajit P YoganathanWallace H. Coulter School of Biomedical Engineering, Georgia Institute of Technology, 387 Technology Circle, Suite 232, Atlanta, GA, 30313-2412, USA. ajit.yoganathan@bme.gatech.edu.ORCID http://orcid.org/0000-0001-5818-1316
Georgia Institute of Technology · USChildren's Hospital of Philadelphia · USEmory University · US

Funding

Improving Flow Dynamics in Fontan SurgeriesR01HL067622 · NHLBI · GEORGIA INSTITUTE OF TECHNOLOGY · PI YOGANATHAN, AJIT P · 2002 to 2006
$5.2M
Understanding mechanisms of Fontan failure and key predictors for patient outcomeR01HL098252 · NHLBI · GEORGIA INSTITUTE OF TECHNOLOGY · PI YOGANATHAN, AJIT P · 2010 to 2013
$3.0M
Georgia Institute of Technology Petit Undergraduate Research ScholarshipNHLBI NIH HHS HL098252NHLBI NIH HHS HL67622NHLBI NIH HHS R01 HL067622NHLBI NIH HHS R01 HL098252
6 · The paper itself

Abstract

Computational fluid dynamic (CFD) simulations are widely utilized to assess Fontan hemodynamics that are related to long-term complications. No previous studies have systemically investigated the effects of using different inlet velocity profiles in Fontan simulations. This study implements real, patient-specific velocity profiles for numerical assessment of Fontan hemodynamics using CFD simulations. Four additional, artificial velocity profiles were used for comparison: (1) flat, (2) parabolic, (3) Womersley, and (4) parabolic with inlet extensions [to develop flow before entering the total cavopulmonary connection (TCPC)]. The differences arising from the five velocity profiles, as well as discrepancies between the real and each of the artificial velocity profiles, were quantified by examining clinically important metrics in TCPC hemodynamics: power loss (PL), viscous dissipation rate (VDR), hepatic flow distribution, and regions of low wall shear stress. Statistically significant differences were observed in PL and VDR between simulations using real and flat velocity profiles, but differences between those using real velocity profiles and the other three artificial profiles did not reach statistical significance. These conclusions suggest that the artificial velocity profiles (2)-(4) are acceptable surrogates for real velocity profiles in Fontan simulations, but parabolic profiles are recommended because of their low computational demands and prevalent applicability.

Indexed as

Computer SimulationFontan ProcedureHemodynamicsModels, CardiovascularAdolescentChildFemaleHumansHydrodynamicsMalePulmonary ArteryComputational fluid dynamicsFontan hemodynamicsInlet velocity profiles

Identifiers

PMID31236791
PMCPMC6842101
OpenAlexW2955976638

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.