Evidence map›Paper›PMID 31236752›Full record

ArticleMikrochimica acta2019

Manganese(II)-doped zinc/germanium oxide nanoparticles as a viable fluorescent probe for visual and time-resolved fluorometric determination of ascorbic acid and its oxidase.

Xin-Yue Han, Zi-Han Chen, Qian-Xi Fan, Kang-Ni Li, Fang-Ya Mu, Qingying Luo, Zongwen Jin, Guoyue Shi, Min Zhang

Abstract read
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In one paragraph

Article in Mikrochimica acta, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Xin-Yue HanSchool of Chemistry and Molecular Engineering, Shanghai Key Laboratory for Urban Ecological Processes and Eco-Restoration, East China Normal University, 500 Dongchuan Road, Shanghai, 200241, China.
Zi-Han ChenSchool of Chemistry and Molecular Engineering, Shanghai Key Laboratory for Urban Ecological Processes and Eco-Restoration, East China Normal University, 500 Dongchuan Road, Shanghai, 200241, China.
Qian-Xi FanSchool of Chemistry and Molecular Engineering, Shanghai Key Laboratory for Urban Ecological Processes and Eco-Restoration, East China Normal University, 500 Dongchuan Road, Shanghai, 200241, China.
Kang-Ni LiSchool of Chemistry and Molecular Engineering, Shanghai Key Laboratory for Urban Ecological Processes and Eco-Restoration, East China Normal University, 500 Dongchuan Road, Shanghai, 200241, China.
Fang-Ya MuSchool of Chemistry and Molecular Engineering, Shanghai Key Laboratory for Urban Ecological Processes and Eco-Restoration, East China Normal University, 500 Dongchuan Road, Shanghai, 200241, China.
Qingying LuoResearch Center for Micro/Nano System & Bionic Medicine, Institute of Biomedical & Health Engineering, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, 1068 Xueyuan Avenue, Shenzhen, 518055, China.
Zongwen JinResearch Center for Micro/Nano System & Bionic Medicine, Institute of Biomedical & Health Engineering, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, 1068 Xueyuan Avenue, Shenzhen, 518055, China.
Guoyue ShiSchool of Chemistry and Molecular Engineering, Shanghai Key Laboratory for Urban Ecological Processes and Eco-Restoration, East China Normal University, 500 Dongchuan Road, Shanghai, 200241, China.
Min ZhangSchool of Chemistry and Molecular Engineering, Shanghai Key Laboratory for Urban Ecological Processes and Eco-Restoration, East China Normal University, 500 Dongchuan Road, Shanghai, 200241, China. mzhang@chem.ecnu.edu.cn.ORCID 0000-0001-5108-1275

Funding

Guangdong Science and Technology Department (CN) 2016B020238003Key Project of the Shanghai Science and Technology Committee 18DZ1112700National Natural Science Foundation of China 21635003National Natural Science Foundation of China 21675053National Natural Science Foundation of China 21775044Natural Science Foundation of Shanghai 19ZR1473300
6 · The paper itself

Abstract

A method is described for the determination of ascorbic acid (AA) in complex biological fluids. It based on maganese(II)-doped zinc/germanium oxide nanoparticles (Mn@ZnGe NPs) with appealing time-resolved phosphorescence (TRP). TRP can provide a background-free reporter signal in analytical methods. The absorption of AA overlaps the excitation band of Mn@ZnGe NPs at 254 nm. This reduces the intensity of fluorescence via an inner filter effect (IFE) with increasing concentration of AA. Typical experimental conditions include an emission peak at 536 nm, a delay time of 50 μs and a counting time of 2 ms. This method can detect AA in a range of 5-500 μM with a 0.13 μM limit of detection. If AA is oxidized by the enzyme AA oxidase (AAOx), dehydroascorbic acid will be formed which doesn't absorb at 254 nm. Hence, the IFE cannot occur and fluorescence is not reduced. The strategy can be used to quantify AAOx in the activity range of 1-4 U·mL

Indexed as

AnimalsAscorbate OxidaseAscorbic AcidEnzyme AssaysFluorescent DyesGermaniumLimit of DetectionMaleManganeseMetal NanoparticlesRatsSmartphoneSpectrometry, FluorescenceZincAscorbate OxidaseAscorbic AcidFluorescent DyesGermaniumgermanium oxideManganeseZincInner-filter effectReal-time/onsite quantitative scanometric monitoringTime-resolved phosphorescenceVisual biosensing

Identifiers

PMID31236752

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