ArticleClinical rheumatology2019
Impact of the gene-gene interactions related to the HIF-1α signaling pathway with the knee osteoarthritis development.
Article in Clinical rheumatology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Osteoarthritis: Epidemiology, Diagnosis, and Treatment.MedComm · 2026Review
- MiR203a-3p as a potential biomarker for synovial pathology associated with osteoarthritis: a pilot study.Journal of orthopaedic surgery and research · 2024Article
- RNA sequencing reveals the circular RNA expression profiles of the infrapatellar fat pad/synovium unit.Annals of translational medicine · 2021Article
- Association study of the functional variants of the GLIS3 gene with risk of knee osteoarthritis.Clinical rheumatology · 2021Article
- Cartilage Targets of Knee Osteoarthritis Shared by Both Genders.International journal of molecular sciences · 2021Article
- Multifactor dimensionality reduction reveals a strong gene-gene interaction between STC1 and COL11A1 genes as a possible risk factor of knee osteoarthritis.Molecular biology reports · 2020Article
- Hypoxia-inducible factor-1 alpha maintains mouse articular cartilage through suppression of NF-κB signaling.Scientific reports · 2020Article
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13 authors.
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Abstract
INTRODUCTION/
objectivesArticular cartilage is the target tissue of osteoarthritis (OA), and because it lacks capillary networks, the microenvironment is hypoxic. Hypoxia inducible factor-1 alpha (HIF-1α) regulates the homeostasis of this tissue. The aim of this study was to investigate whether genetic polymorphisms of the HIF-1α signaling pathway are involved in the development of knee OA.
methodWe performed a case-control association study and genotyped 134 knee OA patients and 267 healthy controls. All participants were genotyped in order to evaluate 42 SNPs from 22 genes involved in the HIF-1α signaling pathway using the OpenArray technology. Gene-gene interactions (epistasis) were analyzed using the multifactor dimensionality reduction (MDR) method.
resultsThe MDR analysis showed epistasis between AKT2 (rs8100018) and IGF1 (rs2288377), AKT2 (rs8100018) and IGF1 (rs35767), IGF1 (rs35767) and COL2A1 (rs1793953), and between GSK3B (rs6438552) and IGF1 (rs35767) polymorphisms, with information gain values of 21.24%, 8.37%, 9.93%, and 5.73%, respectively. Additionally, our model allowed us to identify high- and low-risk genotypes among COL2A1 rs1793953, GSK3B rs6438552, AKT2 rs8100018, and IGF1 rs35767 polymorphisms.
conclusionsKnowing the interactions of these polymorphisms involved in HIF-1α signaling pathway could provide a new diagnostic support tool to identify individuals at high risk of developing knee OA.
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