ArticleSurgical case reports2019
A case of biliary adenofibroma of the liver with malignant transformation: a morphomolecular case report and review of the literature.
Article in Surgical case reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.
- Imaging features of biliary adenofibroma of the liver with malignant transformation: a case report with literature review.BMC medical imaging · 2022Pooled it
- Benign Biliary Tumors and Precursor Neoplasms: An Updated Clinicopathological and Molecular Review Based on the 2026 WHO Classification.Biomedicines · 2026Review
- Review
- Coexistence of Small Duct Type and Biliary Adenofibroma-Associated Large Duct Type Intrahepatic Cholangiocarcinoma within a Single Lesion: A Case Report.Surgical case reports · 2026Article
- Imaging Findings of Biliary Adenofibroma of the Liver: A Case Report.Journal of the Korean Society of Radiology · 2025Article
- Biliary Adenofibroma and the Threat of Malignant Transformation.International journal of surgical pathology · 2025Review
- Multiple Biliary Adenofibromas with Adenocarcinoma of Gallbladder: Histopathological Conundrum.Journal of gastrointestinal cancer · 2023Article
- Multimodal imaging findings of intrahepatic cholangiocarcinoma arising from a biliary adenofibroma: a case report with radiological-pathological correlation.Abdominal radiology (New York) · 2023Review
- Biliary adenofibroma: a precursor lesion of intrahepatic cholangiocarcinoma.Autopsy & case reports · 2023Article
- Malignant transformation of biliary adenofibroma combined with benign lymphadenopathy mimicking advanced liver carcinoma: A case report.World journal of clinical cases · 2022Article
- Imaging presentation of biliary adenofibroma: A case report.World journal of clinical cases · 2022Article
- Biliary Adenofibroma: A Rare Liver Tumor with Transition to Invasive Carcinoma.Case reports in surgery · 2022Article
- Robotic enucleation of a biliary adenofibroma.BMJ case reports · 2021Article
- A Case Report of Cholangiocarcinoma Arising from a Biliary Adenofibroma: Radiologic Findings and Review of Literature.Taehan Yongsang Uihakhoe chi · 2021Article
- Imaging features of intrahepatic bile duct adenoma in MRI.Translational cancer research · 2020Article
- Hepatic Biliary Adenofibroma: Histological Characteristics, Diagnostic Challenges, and Its Role as a Precursor to Intrahepatic Cholangiocarcinoma.Journal of clinical and translational pathologyArticle
- Atypical Biliary Adenofibroma of the Liver: Related Treatment and Performance.Case reports in gastroenterologyArticle
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBiliary adenofibroma is an exceptionally rare benign liver tumor with the potential for malignant transformation. In literature, only 21 cases have been described. CLINICAL PRESENTATION: In a healthy 63-year-old woman, a partly solid, partly cystic mass in the left lobe of the liver during a routine ultrasound examination was found. The computed tomography (CT) scan of the abdomen showed a 6.3 × 5.0-cm multilobulated cystic, partly hypervascularized mass in the liver segment IVa, with extension into segments II and IVb. There was no evidence of lymph node or distant metastases. Extirpation of the tumor was indicated by the multidisciplinary tumorboard. Microscopic examination showed a biphasic composed tumor with tubules embedded in fibrous stroma. In addition, there were also areas with pseudopapillary projections, as well as parts with focal cribriform-like growth pattern, which have been indicated as a possible sign of malignant transformation. Additionally, we found two different polymorphisms in the encoded TP53 und KIT in both distinct morphology tumor areas by molecular analysis, which ensured a tumor in malignant transformation. The patient has been alive for 24 months after R0 resection without tumor recurrence. Further investigation of more cases of this rare entity is necessary to proof molecular genesis.
conclusionsWe report a rare case of a biliary adenofibroma with transition to an intrahepatic cholangiocellular carcinoma and present a brief literature review.
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