Evidence map›Paper›PMID 31236612›Full record

ArticleEuropean biophysics journal : EBJ2019

Stochastic and deterministic approaches to modelling calcium release in cardiac myocytes at different spatial arrangements of ryanodine receptors.

B I Iaparov, A S Moskvin, I Zahradník, A Zahradníková

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Article in European biophysics journal : EBJ, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

B I IaparovResearch Institute of Physics and Applied Mathematics, Ural Federal University, 620083, Yekaterinburg, Russia. bogdan.iaparov@urfu.ru.ORCID http://orcid.org/0000-0002-3398-2093
A S MoskvinResearch Institute of Physics and Applied Mathematics, Ural Federal University, 620083, Yekaterinburg, Russia.
I ZahradníkDepartment of Cellular Cardiology, Institute of Experimental Endocrinology, Biomedical Research Center, University Science Park for Biomedicine, Slovak Academy of Sciences, 845 05, Bratislava, Slovakia.
A ZahradníkováDepartment of Cellular Cardiology, Institute of Experimental Endocrinology, Biomedical Research Center, University Science Park for Biomedicine, Slovak Academy of Sciences, 845 05, Bratislava, Slovakia.ORCID https://orcid.org/0000-0002-7296-9617
Slovak Academy of Sciences · SKUral Federal University · RU

Funding

Agentúra na Podporu Výskumu a Vývoja APVV-15-0302Government Council on Grants, Russian Federation 02.A03.21.0006Ministry of Education and Science of the Russian Federation (RU) 2277Ministry of Education and Science of the Russian Federation (RU) 5719Russian Foundation for Basic Research 18-31-00153
6 · The paper itself

Abstract

Calcium release sites (CRSs) play a key role in excitation-contraction coupling of cardiac myocytes. Recent studies based on electron tomography and super-resolution imaging revealed that CRSs are not completely filled with ryanodine receptors (RyRs) and that the spatial arrangement of RyRs is neither uniform nor static. In this work, we studied the effect of spatial arrangement of RyRs on RyR activation using simulations based on Monte Carlo (MC) and mean-field (MF) approaches. Both approaches showed that activation of RyRs is sensitive to the arrangement of RyRs in the CRS. However, the MF simulations did not reproduce results of MC simulations for non-compact CRSs, suggesting that the approximations used in the MF approach are not suitable for simulation studies of RyRs arrangements observed experimentally. MC simulations revealed the importance of realistic spatial arrangement of RyRs for adequate modelling of calcium release in cardiac myocytes.

Indexed as

Models, BiologicalCalciumMonte Carlo MethodMyocytes, CardiacRyanodine Receptor Calcium Release ChannelStochastic ProcessesCalciumRyanodine Receptor Calcium Release ChannelCalcium release siteCalcium sparksCardiac myocyteMathematical modellingRyanodine receptors

Identifiers

PMID31236612
OpenAlexW2950911346

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.