ArticleMolecular biology and evolution2019
Horizontal Transfer of Bacterial Cytolethal Distending Toxin B Genes to Insects.
Article in Molecular biology and evolution, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 47 citations in OpenAlex.
- Horizontal gene transfer rivals gene duplication as a source of anti-parasitoid immune innovation in the Drosophilidae.bioRxiv : the preprint server for biology · 2026Article
- The genome and stage-specific transcriptomes of the carrot weevil, Listronotus oregonensis, reveal adaptive mechanisms for host specialisation and symbiotic interactions.Insect molecular biology · 2026Article
- Ecological Mercenaries: Why Aphids Remain Premier Models for the Study of Ecological Symbiosis.Insects · 2025Review
- The shape of discovery: a journey through genetics, coevolution, and a scientific life.Genetics · 2025Article
- Experimental horizontal transfer of phage-derived genes to Drosophila confers innate immunity to parasitoids.Current biology : CB · 2025Article
- Pore-Forming Toxin-Like Proteins in the Anti-Parasitoid Immune Response of Drosophila.Journal of innate immunity · 2025Article
- Bdelloid rotifers deploy horizontally acquired biosynthetic genes against a fungal pathogen.Nature communications · 2024Article
- Acquired stress resilience through bacteria-to-nematode interdomain horizontal gene transfer.The EMBO journal · 2023Article
- Extreme genome diversity and cryptic speciation in a harmful algal-bloom-forming eukaryote.Current biology : CB · 2023Article
- Flies co-opt bacterial toxins for use in defense against parasitoids.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Evolution of insect innate immunity through domestication of bacterial toxins.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Horizontally transferred genes as RNA interference targets for aphid and whitefly control.Plant biotechnology journal · 2023Article
- Multiple Horizontal Acquisitions of Plant Genes in the Whitefly Bemisia tabaci.Genome biology and evolution · 2022Article
- Do aphids in Dutch sweet pepper greenhouses carry heritable elements that protect them against biocontrol parasitoids?Evolutionary applications · 2022Article
- Protein evidence of unannotated ORFs ineLife · 2022Article
- Diversity and function of arthropod endosymbiont toxins.Trends in microbiology · 2022Review
- Evolution in small steps and giant leaps.Evolution; international journal of organic evolution · 2022Review
- Genetic innovations in animal-microbe symbioses.Nature reviews. Genetics · 2022Review
- Broad Ultrastructural and Transcriptomic Changes Underlie the Multinucleated Giant Hemocyte Mediated Innate Immune Response against Parasitoids.Journal of innate immunity · 2022Article
- Horizontal Transfer of Microbial Toxin Genes to Gall Midge Genomes.Genome biology and evolution · 2021Article
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Authors and funding
10 authors at 5 institutions in 1 country.
Funding
Abstract
Horizontal gene transfer events have played a major role in the evolution of microbial species, but their importance in animals is less clear. Here, we report horizontal gene transfer of cytolethal distending toxin B (cdtB), prokaryotic genes encoding eukaryote-targeting DNase I toxins, into the genomes of vinegar flies (Diptera: Drosophilidae) and aphids (Hemiptera: Aphididae). We found insect-encoded cdtB genes are most closely related to orthologs from bacteriophage that infect Candidatus Hamiltonella defensa, a bacterial mutualistic symbiont of aphids that confers resistance to parasitoid wasps. In drosophilids, cdtB orthologs are highly expressed during the parasitoid-prone larval stage and encode a protein with ancestral DNase activity. We show that cdtB has been domesticated by diverse insects and hypothesize that it functions in defense against their natural enemies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.