Evidence map›Paper›PMID 31236522›Full record

ArticleNeurobiology of sleep and circadian rhythms2019

Melatonin profiles during the third trimester of pregnancy and health status in the offspring among day and night workers: A case series.

P A Nehme, F G Amaral, B Middleton, A Lowden, E Marqueze, I França-Junior, J L F Antunes, J Cipolla-Neto, D J Skene, C R C Moreno

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurobiology of sleep and circadian rhythms, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05318144 (Prognostic Value of Serum Melatonin as a Biomarker for the Determination of Severe COVID-19 Infection in Pregnant Women), which is not on this map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05318144 completednot on this mapstarted 2021, after this paper: background citation

Prognostic Value of Serum Melatonin as a Biomarker for the Determination of Severe COVID-19 Infection in Pregnant Women

Typeobservational_patient_registrySponsorNazan Yurtcu MDRan2021 to 2022Enrolled228ConditionsCOVID-19 Acute Respiratory Distress Syndrome, Pregnancy Related, Pregnancy Complications
3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  8. Evening blue-light exposure, maternal glucose, and infant birthweight.Annals of the New York Academy of Sciences · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

P A NehmeSchool of Public Health, University of São Paulo, Brazil.
F G AmaralDepartment of Physiology, Federal University of São Paulo, Brazil.
B MiddletonFaculty of Health and Medical Sciences, University of Surrey, UK.
A LowdenStress Research Institute, University of Stockholm, Sweden.
E MarquezeSchool of Public Health, University of São Paulo, Brazil.
I França-JuniorSchool of Public Health, University of São Paulo, Brazil.
J L F AntunesSchool of Public Health, University of São Paulo, Brazil.
J Cipolla-NetoDepartment of Physiology and Biophysics Neurobiology Lab, Institute of Biomedical Sciences, University of São Paulo, Brazil.
D J SkeneFaculty of Health and Medical Sciences, University of Surrey, UK.
C R C MorenoSchool of Public Health, University of São Paulo, Brazil.

Funding

Medical Research Council MR/N006321/1
6 · The paper itself

Abstract

Successful pregnancy requires adaptation in maternal physiology. During intrauterine life the mother's circadian timing system supports successful birth and postnatal development. Maternal melatonin is important to transmit circadian timing and day length to the fetus. This study aims to describe the third trimester of pregnancy among day (n = 5) and night (n = 3) workers by assessing their melatonin levels in a natural environment. Additionally, we describe the worker's metabolic profiles and compare the health status of the newborns between groups of day and night working mothers. Our results indicate an occurrence of assisted delivery (cesarean and forceps) among night workers. Moreover, the newborns of night workers showed lower Apgar index and breastfeeding difficulty indicating a worse condition to deal with the immediate outside the womb environment. Additionally, there was lower night-time melatonin production among pregnant night workers compared to day workers. These findings may be related to light-induced suppression of melatonin that occurs during night work. We conclude that night work and consequent exposure to light at unconventional times might compromise the success of pregnancy and the health of the newborn. Further studies need to be carried out to monitor pregnancy and newborn health in pregnant night workers.

Indexed as

MelatoninMetabolic disturbancesOffspringPregnancyPremature birthShift work

Identifiers

PMID31236522
PMCPMC6586602

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.