Evidence map›Paper›PMID 31236518›Full record

ArticleNeurobiology of sleep and circadian rhythms2019

Electrophysiological characterization of sleep/wake, activity and the response to caffeine in adult cynomolgus macaques.

Anushka V Goonawardena, Stephen R Morairty, Gabriel A Orellana, Adrian R Willoughby, Tanya L Wallace, Thomas S Kilduff

Open access · goldAbstract read
In one paragraph

Article in Neurobiology of sleep and circadian rhythms, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Activation of the nociceptin/orphanin-FQ receptor promotes NREM sleep and EEG slow wave activity.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  4. Impact of daily caffeine intake and timing on electroencephalogram-measured sleep in adolescents.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2022
    Article
  5. Article
  6. Article
  7. Article
  8. Trace amine-associated receptor 1 agonism promotes wakefulness without impairment of cognition in Cynomolgus macaques.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Anushka V GoonawardenaCenter for Neuroscience, Biosciences Division, SRI International, 333 Ravenswood Avenue, Menlo Park, CA 94025, USA.
Stephen R MorairtyCenter for Neuroscience, Biosciences Division, SRI International, 333 Ravenswood Avenue, Menlo Park, CA 94025, USA.
Gabriel A OrellanaCenter for Neuroscience, Biosciences Division, SRI International, 333 Ravenswood Avenue, Menlo Park, CA 94025, USA.
Adrian R WilloughbyCenter for Neuroscience, Biosciences Division, SRI International, 333 Ravenswood Avenue, Menlo Park, CA 94025, USA.
Tanya L WallaceCenter for Neuroscience, Biosciences Division, SRI International, 333 Ravenswood Avenue, Menlo Park, CA 94025, USA.
Thomas S KilduffCenter for Neuroscience, Biosciences Division, SRI International, 333 Ravenswood Avenue, Menlo Park, CA 94025, USA.
SRI International · US

Funding

NEURAL GENE EXPRESSION IN SLEEP DEPRIVATION AND RECOVERYR01HL059658 · NHLBI · STANFORD UNIVERSITY · PI KILDUFF, THOMAS S · 1997 to 2023
$8.7M
U.S.-Japan BRCP Supplement to "The Tuberal Hypothalamus and Arousal State Control"R01NS098813 · NINDS · SRI INTERNATIONAL · PI KILDUFF, THOMAS S · 2016 to 2020
$3.3M
TAAR1 agonists as wake-promoting and cognitive-enhancing therapeuticsR21NS085757 · NINDS · SRI INTERNATIONAL · PI KILDUFF, THOMAS S, WALLACE, TANYA L · 2014 to 2015
$951k
NHLBI NIH HHS R01 HL059658NINDS NIH HHS R01 NS098813NINDS NIH HHS R21 NS085757
6 · The paper itself

Abstract

Most preclinical sleep studies are conducted in nocturnal rodents that have fragmented sleep in comparison to humans who are primarily diurnal, typically with a consolidated sleep period. Consequently, we sought to define basal sleep characteristics, sleep/wake architecture and electroencephalographic (EEG) activity in a diurnal non-human primate (NHP) to evaluate the utility of this species for pharmacological manipulation of the sleep/wake cycle. Adult, 9-11 y.o. male cynomolgus macaques (

Indexed as

A1, Adenosine sub-type 1 receptorA2a, Adenosine sub-type 2 receptorCAF, CaffeineCaffeineCynomolgus macaqueEEGEEG, ElectroencephalogramEMG, Electromyogrami.m., IntramuscularLMA, Locomotor activityN1, NREM Stage 1N2, NREM Stage 2N3, NREM Stage 3NHP, Non-human primateNREMNREM, Non-rapid eye movementREMREM, Rapid eye movementROL, REM onset latencySEM, Standard error of meanSleepSOL, Sleep onset latencyTST, Total sleep timeWASO, Wake after sleep onset

Identifiers

PMID31236518
PMCPMC6586594
OpenAlexW2888581123

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.