Evidence map›Paper›PMID 31236465›Full record

ArticleLaryngoscope investigative otolaryngology2019

Does perioperative oxandrolone improve nutritional status in patients with cachexia related to head and neck carcinoma?

Angela M Osmolak, Cristine N Klatt-Cromwell, Amber M Price, Jose A Sanclement, Greg A Krempl

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Laryngoscope investigative otolaryngology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 8 citations in OpenAlex.

  1. Metabolomics-driven discovery of therapeutic targets for cancer cachexia.Journal of cachexia, sarcopenia and muscle · 2024
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Angela M OsmolakDepartment of Otorhinolaryngology-Head and Neck Surgery University of Oklahoma Oklahoma City Oklahoma U.S.A.ORCID https://orcid.org/0000-0003-3049-549X
Cristine N Klatt-CromwellDepartment of Otorhinolaryngology-Head and Neck Surgery University of Oklahoma Oklahoma City Oklahoma U.S.A.
Amber M PriceDepartment of Otorhinolaryngology-Head and Neck Surgery University of Oklahoma Oklahoma City Oklahoma U.S.A.
Jose A SanclementDepartment of Otorhinolaryngology-Head and Neck Surgery University of Oklahoma Oklahoma City Oklahoma U.S.A.
Greg A KremplDepartment of Otorhinolaryngology-Head and Neck Surgery University of Oklahoma Oklahoma City Oklahoma U.S.A.
Oklahoma City University · USWashington University in St. Louis · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCancer cachexia affects up to over 50% of advanced head and neck cancer (HNC) patients. To date, the potential utility of anabolic steroids in perioperative cachectic HNC patients has not been determined.

methodsRetrospective review of pre- and post-oxandrolone administration prealbumin levels in 18 perioperative HNC patients between October 2007 and October 2014 at a tertiary academic medical center.

resultsThe median pretreatment prealbumin was 88.5 mg/L. The median post-treatment prealbumin was 227 mg/L. The median interval improvement of the prealbumin level was 131.5 mg/L. The median differences between the pretreatment and post-treatment prealbumin levels were found to be statistically significant (

conclusionsPerioperative administration of oxandrolone resulted in objective improvements in prealbumin levels and subjective improvements in surgical wounds. Oxandrolone administered 10 mg twice daily (BID) for 10 days may be a useful adjunct in the perioperative care of nutritionally deficient HNC patients who are at risk for or have demonstrated impaired wound healing. LEVEL OF EVIDENCE: 3.

Indexed as

anabolic steroidscancer cachexiaHead and neck canceroxandroloneprealbumin

Identifiers

PMID31236465
PMCPMC6580053
OpenAlexW2945667636

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.