ArticleEye and vision (London, England)2019
The use of high resolution anterior segment optical coherence tomography for the characterization of conjunctival lymphoma, conjunctival amyloidosis and benign reactive lymphoid hyperplasia.
Article in Eye and vision (London, England), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 34 citations in OpenAlex.
- High-Resolution Anterior Segment Optical Coherence Tomography Characteristics of Conjunctival Tumors.Journal of clinical practice and research · 2026Article
- Imaging of Ocular Surface Lesions Using Anterior Segment Optical Coherence Tomography.Clinical & experimental ophthalmology · 2026Review
- Enhanced Imaging of Ocular Surface Lesions.Journal of clinical medicine · 2025Review
- Can high-resolution optical coherence tomography provide an optical biopsy for ocular surface lesions?Canadian journal of ophthalmology. Journal canadien d'ophtalmologie · 2025Review
- Subepithelial Lesions of the Ocular Surface: A Review.Current ophthalmology reports · 2025Review
- Infectious etiologies of conjunctival tumors.Expert review of ophthalmology · 2025Article
- Characteristics of conjunctival myxomas on anterior segment optical coherence tomography.Canadian journal of ophthalmology. Journal canadien d'ophtalmologie · 2024Article
- Clinical Applications of Anterior Segment Optical Coherence Tomography: An Updated Review.Diagnostics (Basel, Switzerland) · 2024Review
- Conjunctival Lymphoma.Eye (London, England) · 2023Review
- Conjunctival cyst with apocrine hidrocystoma-like features: a case report.International journal of ophthalmology · 2023Article
- The use of high resolution optical coherence tomography (HR-OCT) in the diagnosis of ocular surface masqueraders.The ocular surface · 2022Review
- The role of imaging technologies for ocular surface tumors.Current opinion in ophthalmology · 2021Review
- Optical Coherence Tomography of Peri-Ocular Skin Cancers: An Optical Biopsy.Ocular oncology and pathology · 2021Article
- High resolution anterior segment optical coherence tomography of ocular surface lesions: A review and handbook.Expert review of ophthalmology · 2021Article
- Conjunctival lymphoma: case report.Romanian journal of ophthalmologyArticle
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundConjunctival lymphoma, conjunctival amyloidosis and benign reactive lymphoid hyperplasia (BRLH) are conditions that often have a similar appearance on the ocular surface. The use of high resolution anterior segment optical coherence tomography (HR-OCT) enables clinicians to evaluate distinctive differences in tissue morphology and cellular patterns in various ocular surface conditions. In this study, we characterize the morphological differences seen in conjunctival lymphoma, conjunctival amyloidosis and BRLH on HR-OCT imaging.
methodsA retrospective chart review was performed of patients with biopsy proven conjunctival lymphoma, conjunctival amyloidosis and BRLH between 2012 and 2019 at the Bascom Palmer Eye Institute. Patients were excluded if HR-OCT imaging was not performed on initial presentation.
resultsThirty-four total eyes of 27 patients were identified. Twenty eyes had conjunctival lymphoma (16 patients), 8 eyes had conjunctival amyloidosis (6 patients) and 6 eyes had BRLH (5 patients). All conditions appeared clinically as pink, red or yellow subepithelial lesions but had different features on HR-OCT. In lymphoma, HR-OCT images typically showed homogenous, dark subepithelial lesions with smooth borders, containing monomorphic dot-like infiltrates. HR-OCT images of amyloidosis typically showed heterogeneous, dark lesions with irregular borders, often containing hyperreflective linear infiltrates. HR-OCT images of BRLH showed variable infiltration of the subepithelial tissue, at times with homogenous lesions containing dot-like infiltrates like lymphoma and other times with more hyperreflective, subepithelial tissue. Flow cytometry and gene rearrangement was needed for final differentiation between BRLH and lymphoma lesions.
conclusionsDistinctive features on HR-OCT of conjunctival lymphoma, conjunctival amyloidosis and BRLH can help characterize these lesions beyond what is apparent with the clinical examination. Future studies can further validate this technology's use with more subtle and challenging lesions.
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