Evidence map›Paper›PMID 31236409›Full record

ArticleBioMed research international2019

Focused Ultrasound Effects on Osteosarcoma Cell Lines.

Valentina Agnese, Viviana Costa, Gian Luca Scoarughi, Cristiano Corso, Valeria Carina, Angela De Luca, Daniele Bellavia, Lavinia Raimondi, Stefania Pagani, Massimo Midiri and 5 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BioMed research international, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 1 country.

Valentina AgneseIRCCS Istituto Ortopedico Rizzoli, Via di Barbiano, 1/10 - 40136 Bologna, Italy.
Viviana CostaIRCCS Istituto Ortopedico Rizzoli, Via di Barbiano, 1/10 - 40136 Bologna, Italy.ORCID 0000-0002-2425-6460
Gian Luca ScoarughiPromedica Bioelectronics srl, Dep. Research & Development, Via del Vespro, 129 - 90127 Palermo, Italy.
Cristiano CorsoPromedica Bioelectronics srl, Dep. Research & Development, Via del Vespro, 129 - 90127 Palermo, Italy.
Valeria CarinaIRCCS Istituto Ortopedico Rizzoli, Via di Barbiano, 1/10 - 40136 Bologna, Italy.ORCID 0000-0002-7323-8023
Angela De LucaIRCCS Istituto Ortopedico Rizzoli, Via di Barbiano, 1/10 - 40136 Bologna, Italy.
Daniele BellaviaIRCCS Istituto Ortopedico Rizzoli, Via di Barbiano, 1/10 - 40136 Bologna, Italy.ORCID 0000-0003-3308-9112
Lavinia RaimondiIRCCS Istituto Ortopedico Rizzoli, Via di Barbiano, 1/10 - 40136 Bologna, Italy.ORCID 0000-0001-9394-2002
Stefania PaganiIRCCS Istituto Ortopedico Rizzoli, Via di Barbiano, 1/10 - 40136 Bologna, Italy.
Massimo MidiriSection of Radiological Sciences, University of Palermo, Via del Vespro 127 - 90127 Palermo, Italy.
Giorgio StassiSection of Cellular and Molecular Oncology Section, Department of Surgical, Oncological and Stomatological Sciences, University of Palermo, Via del Vespro 131 - 90134 Palermo, Italy.
Riccardo AlessandroDepartment of Biomedicine, Neuroscience and Advanced Diagnostics, Section of Biology and Genetics, University of Palermo, Via Divisi 83 - 90133 Palermo, Italy.ORCID 0000-0002-9935-1040
Milena FiniIRCCS Istituto Ortopedico Rizzoli, Via di Barbiano, 1/10 - 40136 Bologna, Italy.ORCID 0000-0002-3732-3570
Gaetano BarbatoPromedica Bioelectronics srl, Dep. Research & Development, Via del Vespro, 129 - 90127 Palermo, Italy.
Gianluca GiavaresiIRCCS Istituto Ortopedico Rizzoli, Via di Barbiano, 1/10 - 40136 Bologna, Italy.ORCID 0000-0001-7843-5969
Istituto Ortopedico Rizzoli · ITUniversity of Palermo · ITIstituto di Biomedicina e di Immunologia Molecolare Alberto Monroy · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

MRI guided Focused Ultrasound (MRgFUS) has shown to be effective therapeutic modality for non-invasive clinical interventions in ablating of uterine fibroids, in bone metastasis palliative treatments, and in breast, liver, and prostate cancer ablation. MRgFUS combines high intensity focused ultrasound (HIFU) with MRI images for treatment planning and real time thermometry monitoring, thus enabling non-invasive ablation of tumor tissue. Although in the literature there are several studies on the Ultrasound (US) effects on cell in culture, there is no systematic evidence of the biological effect of Magnetic Resonance guided Focused Ultrasound Surgery (MRgFUS) treatment on osteosarcoma cells, especially in lower dose regions, where tissues receive sub-lethal acoustic power. The effect of MRgFUS treatment at different levels of acoustic intensity (15.5-49 W/cm

Indexed as

Bone NeoplasmsCell Line, TumorCell SurvivalHigh-Intensity Focused Ultrasound AblationHumansMagnetic Resonance ImagingOsteogenesisOsteosarcomaPhantoms, ImagingSurgery, Computer-AssistedThermometry

Identifiers

PMID31236409
PMCPMC6545756
OpenAlexW2946588563

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.