ArticleWorld journal of clinical cases2019
Elevated levels of interleukin-1β, interleukin-6, tumor necrosis factor-α and vascular endothelial growth factor in patients with knee articular cartilage injury.
Article in World journal of clinical cases, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 33 citations in OpenAlex.
- The Effect of Intravascular Laser Irradiation of Blood on Serum Biomarkers and Clinical Outcome in Knee Osteoarthritis Patients: A Double-Blind Randomized Control Trial.International journal of molecular sciences · 2024Trial
- Inflammatory Cytokine-Mediated Interactions Between Pain and Insomnia: Mechanisms and Therapeutic Implications.Journal of pain research · 2026Review
- Targeting Chondrocyte Hypertrophy as Strategies for the Treatment of Osteoarthritis.Bioengineering (Basel, Switzerland) · 2025Review
- Therapeutic outcomes of combined Bupivacaine Liposome, 1,4-Butanediol Diglycidyl Ether-crosslinked sodium hyaluronate, and arthroscopic debridement in knee osteoarthritis management.American journal of translational research · 2025Article
- Engineered mesenchymal stromal cells with interleukin-1beta sticky-trap attenuate osteoarthritis in knee joints.Frontiers in cell and developmental biology · 2025Article
- Serum biomarkers for diagnosis and severity evaluation in knee osteoarthritis.American journal of translational research · 2025Article
- Comparison of Biomarkers Playing a Role in Pterygium Development in Pterygium and Recurrent Pterygium Tissues.Diagnostics (Basel, Switzerland) · 2024Article
- Association between psychological stress and mandibular condyle structure: an analytical cross-sectional study.BMC musculoskeletal disorders · 2024Article
- Osteoarthritis: Insights into Diagnosis, Pathophysiology, Therapeutic Avenues, and the Potential of Natural Extracts.Current issues in molecular biology · 2024Review
- Potential therapeutic strategies for osteoarthritis via CRISPR/Cas9 mediated gene editing.Reviews in endocrine & metabolic disorders · 2024Review
- Inflammatory and Metabolic Signaling Interfaces of the Hypertrophic and Senescent Chondrocyte Phenotypes Associated with Osteoarthritis.International journal of molecular sciences · 2023Review
- Inflammatory Process on Knee Osteoarthritis in Cyclists.Journal of clinical medicine · 2023Review
- Interleukin-6 neutralization and regulatory T cells are additive in chondroprotection from IL-1β-induced inflammation.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2023Article
- Silk-based hydrogel incorporated with metal-organic framework nanozymes for enhanced osteochondral regeneration.Bioactive materials · 2023Article
- Circulating levels of inflammatory cytokines and angiogenesis-related growth factors in patients with osteoarthritis after COVID-19.Frontiers in medicine · 2023Article
- The Protective Effect of Selenium Nanoparticles in Osteoarthritis: In vitro and in vivo Studies.Drug design, development and therapy · 2023Article
- Enrichment of inflammatory mediators in the synovial fluid is associated with slower progression of mild to moderate osteoarthritis in the porcine knee.American journal of translational research · 2021Article
- A roadmap to target interleukin-6 in osteoarthritis.Rheumatology (Oxford, England) · 2020Article
- [Mechanical stress promotes cartilage repair in inflammatory environment].Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2019Article
- Anti-inflammatory effects of Glycyrrhiza glabra homeopathic formulations in a rat model of lipopolysaccharide-induced inflammation.Journal of Ayurveda and integrative medicineArticle
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundInflammatory cytokines play a vital role in the occurrence of osteoarticular injury and inflammation. Whether inflammation-associated factors interleukin-1β (IL-1β), IL-6, tumor necrosis factor-α (TNF-α) and vascular endothelial growth factor (VEGF) are involved in the pathogenesis of keen articular cartilage injury remains poorly understood.
aimTo measure the levels of inflammatory factors [IL-1β, IL-6, TNF-α and VEGF] in patients with knee articular cartilage injury.
methodsFifty-five patients with knee articular cartilage injury were selected as patient groups, who were divided into three grades [mild (
resultsCompared with the control group, patient groups displayed significantly higher levels of IL-1β, IL-6, TNF-α and VEGF, and the extent of increase was directly proportional to the severity of injury (
conclusionIL-1β, IL-6, TNF-α and VEGF levels are increased in patients with knee articular cartilage injury, and are associated with the disease severity, indicating they might play an important role in the occurrence and development of knee articular cartilage injury. Furthermore, therapeutically targeting them might be a novel approach for the treatment of keen articular cartilage injury.
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