Evidence map›Paper›PMID 31236065›Full record

ArticleMediators of inflammation2019

Neutrophils Are Dysregulated in Patients with Hereditary Angioedema Types I and II in a Symptom-Free Period.

Tereza Grymova, Marcela Vlkova, Premysl Soucek, Roman Hakl, Jana Nechvatalova, Peter Slanina, Julie Stichova, Jiri Litzman, Tomas Freiberger

Open access · goldAbstract read
In one paragraph

Article in Mediators of inflammation, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.4field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 9 citations in OpenAlex.

  1. Role of neutrophils in regulating vascular permeability in inflammatory and autoimmune diseases.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026
    Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Frontiers in allergy · 2022
    Review
  7. Article
  8. Roles of Immune Cells in Hereditary Angioedema.Clinical reviews in allergy & immunology · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Tereza GrymovaCentre for Cardiovascular Surgery and Transplantation, Brno, Czech Republic.
Marcela VlkovaDepartment of Clinical Immunology and Allergology, Faculty of Medicine, Masaryk University, Brno, Czech Republic.
Premysl SoucekCentre for Cardiovascular Surgery and Transplantation, Brno, Czech Republic.ORCID 0000-0002-9985-2531
Roman HaklDepartment of Clinical Immunology and Allergology, Faculty of Medicine, Masaryk University, Brno, Czech Republic.
Jana NechvatalovaDepartment of Clinical Immunology and Allergology, Faculty of Medicine, Masaryk University, Brno, Czech Republic.
Peter SlaninaDepartment of Clinical Immunology and Allergology, Faculty of Medicine, Masaryk University, Brno, Czech Republic.
Julie StichovaDepartment of Clinical Immunology and Allergology, Faculty of Medicine, Masaryk University, Brno, Czech Republic.
Jiri LitzmanDepartment of Clinical Immunology and Allergology, Faculty of Medicine, Masaryk University, Brno, Czech Republic.ORCID 0000-0002-1926-5426
Tomas FreibergerCentre for Cardiovascular Surgery and Transplantation, Brno, Czech Republic.ORCID 0000-0001-6532-7053
Masaryk University · CZCentral European Institute of Technology · CZ

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neutrophils impact on processes preceding the formation of bradykinin, a major swelling mediator in hereditary angioedema (HAE), yet their potential role in HAE pathogenesis has not been sufficiently studied. We assessed the relative mRNA expression of 10 genes related to neutrophil activation using RNA extracted from the peripheral blood neutrophils of 23 HAE patients in a symptom-free period and 39 healthy donors. Increased relative mRNA expression levels of

Indexed as

AdolescentAdultB7-H1 AntigenCD11b AntigenCells, CulturedChildEnzyme-Linked Immunosorbent AssayFlow CytometryHereditary Angioedema Types I and IIHumansInterleukin-1betaInterleukin 1 Receptor Antagonist ProteinInterleukin-8Leukocytes, MononuclearMatrix Metalloproteinase 9NeutrophilsB7-H1 AntigenCD11b AntigenIL1B protein, humanIL1RN protein, humanInterleukin-1betaInterleukin 1 Receptor Antagonist ProteinInterleukin-8Matrix Metalloproteinase 9Pancreatic ElastasePeroxidaseReceptors, IgGReceptors, Urokinase Plasminogen ActivatorRNA, MessengerToll-Like Receptor 4

Identifiers

PMID31236065
PMCPMC6545807
OpenAlexW2946540208

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.