ArticleNature neuroscience2019
TREM2 function impedes tau seeding in neuritic plaques.
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Article in Nature neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 195 papers, 2 of them syntheses that pooled it.
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195citing papers in PubMed, 2 pooled it
–field-weighted citation impact
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
195 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Neuroinflammatory markers sTREM2 and YKL-40 in association with Alzheimer's disease pathology: a systematic review and meta-analysis.Molecular psychiatry · 2026Pooled it
- Gain-of-function Modulation of TREM2 and its Impact on Amyloid-β and Tau Pathologies in Alzheimer's Disease: A Systematic Review and Meta-analysis of Animal Studies.Molecular neurobiology · 2026Pooled it
- Preclinical and first-in-human evaluation of AL002, a novel TREM2 agonistic antibody for Alzheimer's disease.Alzheimer's research & therapy · 2024Trial
- The TREM2 R47H variant is associated with liver-plasma-brain axis dyshomeostasis in the 5xFAD mouse model of Alzheimer's disease.Neurobiology of aging · 2026Article
- TREM2 in neurodegenerative diseases and acute neurological injuries: mechanisms to targeted therapies.Cell communication and signaling : CCS · 2026Review
- Recent advances in Alzheimer's disease: From molecular mechanisms to therapeutic strategies.Cell · 2026Review
- Microglia and neuroinflammation: function, heterogeneity, and crosstalk.Cellular & molecular immunology · 2026Review
- TREM2 in neurodegeneration and diseases.Molecular psychiatry · 2026Review
- Review
- Mechanisms of increased Alzheimer's disease pathology with R47H and R62H TREM2 variants.Acta neuropathologica · 2026Article
- Multiscale Approximations to Understand the Complex Role of Microglia in Alzheimer's Disease.The European journal of neuroscience · 2026Review
- Abi3Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- TREM2 deficiency causes region-specific brain effects in a mouse model of cerebral amyloid angiopathy.bioRxiv : the preprint server for biology · 2026Article
- Plasma Autoantibodies Against Neurodegeneration-Related Antigens in Dementia and Elevated Chi3Li Autoantibodies in Mild Cognitive Impairment.Biomolecules · 2026Article
- Dietary Bioactives in Alzheimer's Disease: A Critical Appraisal of Clinical Trials and Future Nutritional Strategies.Nutrients · 2026Review
- Immune dysfunction in Alzheimer disease.Nature reviews. Neuroscience · 2026Review
- Targeting tau in Alzheimer's Disease: rationale, approach and challenges.Molecular neurodegeneration · 2026Review
- Neuronal guidance signaling in neurodegenerative diseases: Key regulators that function at neuron-glia and neuroimmune interfaces.Neural regeneration research · 2026Article
- Non-compacted, PET-insensitive amyloid states increase after systemic inflammation and predict neuritic damage across Aβ pathology models and Alzheimer patients.Research square · 2026Article
- Interplay between CD33 and TREM2 in Alzheimer's Disease: Potential Mechanistic Insights into Microglial Function in Amyloid Pathology.ACS chemical neuroscience · 2026Review
135 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Cheryl E G Leyns *Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA.ORCID http://orcid.org/0000-0001-5513-7758
Maud Gratuze *Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA.
Sneha NarasimhanDepartment of Pathology and Laboratory Medicine, Institute on Aging and Center for Neurodegenerative Disease Research, University of Pennsylvania School of Medicine, Philadelphia, PA, USA.
Nimansha JainDepartment of Neurology, Washington University School of Medicine, St. Louis, MO, USA.
Lauren J KoscalDepartment of Neurology, Washington University School of Medicine, St. Louis, MO, USA.
Hong JiangDepartment of Neurology, Washington University School of Medicine, St. Louis, MO, USA.
Melissa ManisDepartment of Neurology, Washington University School of Medicine, St. Louis, MO, USA.ORCID http://orcid.org/0000-0001-7912-2016
Marco ColonnaHope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO, USA.
Virginia M Y LeeDepartment of Pathology and Laboratory Medicine, Institute on Aging and Center for Neurodegenerative Disease Research, University of Pennsylvania School of Medicine, Philadelphia, PA, USA.
Jason D UlrichDepartment of Neurology, Washington University School of Medicine, St. Louis, MO, USA. ulrichjd@wustl.edu.ORCID http://orcid.org/0000-0002-4743-926X
David M HoltzmanDepartment of Neurology, Washington University School of Medicine, St. Louis, MO, USA. holtzman@wustl.edu.ORCID http://orcid.org/0000-0002-3400-0856
Funding
Smartphone-Based "Burst" Cognitive AssessmentsP01AG003991 · NIA · WASHINGTON UNIVERSITY · PI Carlos Cruchaga · 1985 to 2026
$69.5MWASHINGTON UNIVERSITY ALZHEIMERS DISEASE RESEARCH CENTERP50AG005681 · NIA · WASHINGTON UNIVERSITY · PI MORRIS, JOHN · 1985 to 2019
$52.1MThe natural history of AB accumulation in preclinical ADP01AG026276 · NIA · WASHINGTON UNIVERSITY · PI MORRIS, JOHN · 2005 to 2025
$49.5MTransgenic Mouse Models of Tau PathologiesP01AG017586 · NIA · UNIVERSITY OF PENNSYLVANIA · PI LEE, VIRGINIA M · 2000 to 2021
$37.3MEffect of APOE on CNS Neurons: Role of LRPRF1NS090934 · NINDS · WASHINGTON UNIVERSITY · PI HOLTZMAN, DAVID M. · 2020 to 2025
$6.5MTREM2 IN MICROGLIA BIOLOGY AND ALZHEIMER'S DISEASERF1AG051485 · NIA · WASHINGTON UNIVERSITY · PI COLONNA, MARCO · 2015 to 2021
$3.5MEffect of APOE on CNS Neurons: Role of LRPR01NS090934 · NINDS · WASHINGTON UNIVERSITY · PI HOLTZMAN, DAVID M. · 2014 to 2018
$3.0MTHERAPEUTIC STRATEGIES FOR ALZHEIMER'S DISEASE BASED ON TREM2 BIOLOGYRF1AG059082 · NIA · WASHINGTON UNIVERSITY · PI COLONNA, MARCO · 2019 to 2019
$2.6MAPOE EFFECT ON CNS NEURONS--ROLE OF LRPR01AG013956 · NIA · WASHINGTON UNIVERSITY · PI HOLTZMAN, DAVID M · 1996 to 2003
$1.2MZEISS LSM880 AIRYSCAN MICROSCOPE FOR SHARED BIOMEDICAL RESEARCHS10OD021629 · OD · WASHINGTON UNIVERSITY · PI FITZPATRICK, JAMES ALEXANDER · 2017 to 2017
$596kIMPACT OF NOVEL REGULATORS OF TREM2 EXPRESSION ON ALZHEIMER'S DISEASER21AG059176 · NIA · WASHINGTON UNIVERSITY · PI COLONNA, MARCO · 2018 to 2019
$419kMolecular approaches for understanding and advancing tau immunotherapiesF31AG053976 · NIA · WASHINGTON UNIVERSITY · PI LEYNS, CHERYL ELIZABETH GRACE · 2016 to 2018
$67kNIA NIH HHS F31 AG053976NIA NIH HHS P01 AG003991NIA NIH HHS P01 AG017586NIA NIH HHS P01 AG026276NIA NIH HHS P50 AG005681NIA NIH HHS R01 AG013956NIA NIH HHS R01 AG059082NIA NIH HHS R21 AG059176NIA NIH HHS RF1 AG051485NIA NIH HHS RF1 AG059082NIH HHS S10 OD021629NINDS NIH HHS RF1 NS090934
Abstract
Variants in the triggering receptor expressed on myeloid cells 2 (TREM2) have been associated with increased risk for sporadic, late-onset Alzheimer's disease. Here we show that germline knockout of Trem2 or the TREM2
Indexed as
AnimalsCerebral CortexMembrane GlycoproteinsMiceMice, KnockoutMicrogliaPlaque, AmyloidReceptors, ImmunologicTauopathiestau ProteinsMembrane GlycoproteinsReceptors, Immunologictau ProteinsTrem2 protein, mouse
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Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.