SynthesisInternational journal of impotence research2020
Effect of treatment with testosterone on endothelial function in hypogonadal men: a systematic review and meta-analysis.
Synthesis in International journal of impotence research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 27 citations in OpenAlex.
- Review
- Impacts of systemic milieu on cerebrovascular and brain aging: insights from heterochronic parabiosis, blood exchange, and plasma transfer experiments.GeroScience · 2025Review
- New Horizons: Testosterone or Exercise for Cardiometabolic Health in Older Men.The Journal of clinical endocrinology and metabolism · 2023Article
- The sex-dependent response to psychosocial stress and ischaemic heart disease.Frontiers in cardiovascular medicine · 2023Review
- Worsening effect of testosterone deficiency on males with heart failure with preserved ejection fraction.BMC endocrine disorders · 2022Article
- The role of testosterone in male sexual function.Reviews in endocrine & metabolic disorders · 2022Review
- Article
- Serum concentrations of dihydrotestosterone are associated with symptoms of hypogonadism in biochemically eugonadal men.Journal of endocrinological investigation · 2021Article
- Assessing and Addressing Cardiovascular Health in People Who Are Transgender and Gender Diverse: A Scientific Statement From the American Heart Association.Circulation · 2021Review
- Love in the time of COVID-19: a scoping review on male sexual health.Journal of community hospital internal medicine perspectives · 2021Article
- Potential impacts of COVID-19 on reproductive health: Scientific findings and social dimension.Saudi journal of biological sciences · 2021Review
- Addressing male sexual and reproductive health in the wake of COVID-19 outbreak.Journal of endocrinological investigation · 2021Review
- Sex Differences in Cardiovascular Aging and Heart Failure.Current heart failure reports · 2020Review
- Undiagnosed prediabetes status is associated with a reduced effectiveness of phosphodiesterase type 5 inhibitors in men with erectile dysfunction.International journal of impotence research · 2020Article
- Sex differences in vascular aging in response to testosterone.Biology of sex differences · 2020Review
- Monitoring testosterone replacement therapy with transdermal gel: when and how?Journal of endocrinological investigation · 2019Article
Corrections and comments
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Authors and funding
10 authors at 7 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Despite several studies showing an inverse correlation of total testosterone with endothelial damage, the effect of testosterone replacement therapy (TTh) on endothelial function has been scarcely investigated. In order to systematically assess the relationship between endothelial dysfunction and TTh, we performed a review and meta-analysis of available prospective and cross-sectional studies. A thorough research was performed on MEDLINE for hypogonadism and endothelial dysfunction. We retrieved 28 papers, among which 23 were excluded for different reasons: five papers accounting for six studies (two crossover randomized clinical trial (RCT), three observational, one placebo controlled RCT) were therefore included in analysis. Overall, 86 patients with hypogonadism were included in analysis (mean age 49.57 ± 8.85 years). Baseline total testosterone serum levels were 8.11 ± 2.42 nmol/L and significantly increased while undergoing TTh (standard mean difference (SMD) 2.93 nmol/L, 95% confidence interval (CI) 1.89:3.97, p < 0.001). Due to the paucity of studies available, flow-mediated dilation (FMD) was chosen as the best surrogate marker of endothelial dysfunction. FMD did not significantly change after testosterone administration (SMD -0.22, 95% CI -1.29:0.84, I
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