ArticleScientific reports2019
Gut Microbiota Alteration is Characterized by a Proteobacteria and Fusobacteria Bloom in Kwashiorkor and a Bacteroidetes Paucity in Marasmus.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 33 papers, 1 of them a synthesis that pooled it.
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Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.
- Systematic review of associations between gut microbiome composition and stunting in under-five children.NPJ biofilms and microbiomes · 2024Pooled it
- Trial
- Survival status and predictors of mortality among children with severe acute malnutrition admitted to public health facilities at Hawassa City, Southern Ethiopia: a retrospective cohort study.Journal of health, population, and nutrition · 2025Article
- Probiotic administration correlated with reduced diarrheal incidence and improved gut microbiota diversity in young goats.Frontiers in veterinary science · 2025Article
- The human gut microbiome in health and disease: time for a new chapter?Infection and immunity · 2024Review
- Ruminal microbiota and muscle metabolome characteristics of Tibetan plateau yaks fed different dietary protein levels.Frontiers in microbiology · 2024Article
- Antin-diabetic cognitive dysfunction effects and underpinning mechanisms of phytogenic bioactive peptides: a review.Frontiers in nutrition · 2024Review
- Gut dysbiosis: Ecological causes and causative effects on human disease.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- A Scoping Review Evaluating the Current State of Gut Microbiota Research in Africa.Microorganisms · 2023Article
- The intersection of undernutrition, microbiome, and child development in the first years of life.Nature communications · 2023Review
- In Vitro Digestion and Fecal Fermentation of Low-Gluten Rice and Its Effect on the Gut Microbiota.Foods (Basel, Switzerland) · 2023Article
- Increased fecal ethanol and enriched ethanol-producing gut bacteriaFrontiers in cellular and infection microbiology · 2023Article
- Lentinan improves intestinal inflammation and gut dysbiosis in antibiotics-induced mice.Scientific reports · 2022Article
- Research on the Gut Microbiota of Hainan Black Goat.Animals : an open access journal from MDPI · 2022Article
- Article
- Weizmannia faecalis sp. nov., isolated from a human stool sample.Archives of microbiology · 2022Article
- Gut Microbiota Composition in Undernourished Children Associated with Diet and Sociodemographic Factors: A Case-Control Study in Indonesia.Microorganisms · 2022Article
- The role of albumin and the extracellular matrix on the pathophysiology of oedema formation in severe malnutrition.EBioMedicine · 2022Article
- Konateibacter massiliensis gen. nov. sp. nov. and Paenibacillus faecalis sp. nov., Two New Species Isolated from the Stool Samples of Infants Suffering from Marasmus.Current microbiology · 2022Article
- The Mediating Role of the Gut Microbiota in the Physical Growth of Children.Life (Basel, Switzerland) · 2022Review
Corrections and comments
- Retraction · 2023-10-30Lack of IRB/IACUC Approval and/or Compliance · Objections by Author(s) ·
- Retracted
Authors and funding
11 authors at 7 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Kwashiorkor and marasmus are considered to be two different clinical diseases resulting from severe malnutrition, but this distinction has been questioned. In a previous study comparing children with kwashiorkor and healthy children from Niger and Senegal, we found a dramatic gut microbiota alteration with a predominant depletion of anaerobes and enrichment in Proteobacteria and Fusobacteria in kwashiorkor. However, it remained unknown whether this association was related to malnutrition or was a specific feature of kwashiorkor. In this continuation study, we added 7 new marasmus subjects and 71,162 new colonies from the same countries. Our results showed that, compared to marasmus, the kwashiorkor gut microbiota was characterized by an increased proportion of Proteobacteria (culturomics, Marasmus 5.0%, Kwashiorkor 16.7%, p < 0.0001; metagenomics, Marasmus 14.7%, Kwashiorkor 22.0%, p = 0.001), but there was a decreased proportion of Bacteroidetes in marasmus (culturomics, Marasmus 0.8%, Kwashiorkor 6.5%, p = 0.001; metagenomics, Marasmus 5.4%, Kwashiorkor 7.0%, p = 0.03). Fusobacterium was more frequently cultured from kwashiorkor. All detected potential pathogenic species were enriched in the kwashiorkor gut microbiota. These results provide a biological basis to support the usage of an antibiotic therapy more effective in suppressing the overgrowth of bacterial communities resistant to penicillin, combined with antioxidants and probiotics for nutritional recovery therapies, particularly for kwashiorkor.
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