ArticleScientific reports2019
Healthy adiposity and extended lifespan in obese mice fed a diet supplemented with a polyphenol-rich plant extract.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 38 citations in OpenAlex.
- Polyphenol-Rich Beverage Consumption Affecting Parameters of the Lipid Metabolism in Healthy Subjects.International journal of molecular sciences · 2023Trial
- Plant-derived betaine enhances barrier integrity and immune responses in canine intestinal epithelial cells and macrophages under endotoxin challenge.Journal of animal science · 2026Article
- The Effect of Newly Designed High-Antioxidant Food Products on Oxidative Stress and Antioxidant Markers in Athletes.Antioxidants (Basel, Switzerland) · 2025Article
- The Modification of Dietary Protein with Ammonium Hydroxide Enhancement Improves Longevity and Metabolic Outcomes in a Sex-Dependent Manner.Nutrients · 2024Article
- Effects of Active Ingredients in Alcoholic Beverages and Their De-Alcoholized Counterparts on High-Fat Diet Bees: A Comparative Study.Molecules (Basel, Switzerland) · 2024Article
- MOMASTAntioxidants (Basel, Switzerland) · 2023Article
- Emerging cellular senescence-centric understanding of immunological aging and its potential modulation through dietary bioactive components.Biogerontology · 2022Review
- Brown to White Fat Transition Overlap With Skeletal Muscle During Development of Larger Mammals: Is it a Coincidence?Journal of the Endocrine Society · 2022Review
- The Role of Diet in Regulation of Macrophages Functioning.Biomedicines · 2022Review
- Article
- Dietary Plant Extracts Improve the Antioxidant Reserves in Weaned Piglets.Antioxidants (Basel, Switzerland) · 2021Article
- Short-Term Changes in Metabolically Healthy Overweight/Obesity Status Impact the Susceptibility to Type 2 Diabetes in Chinese Adults.Diabetes, metabolic syndrome and obesity : targets and therapy · 2021Article
- High prevalence for obesity in severe COVID-19: Possible links and perspectives towards patient stratification.Biochimie · 2020Article
- Dietary polyphenols in lipid metabolism: A role of gut microbiome.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2020Review
- Adipolin/C1q/Tnf-related protein 12 prevents adverse cardiac remodeling after myocardial infarction.PloS one · 2020Article
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Obesity may not be consistently associated with metabolic disorders and mortality later in life, prompting exploration of the challenging concept of healthy obesity. Here, the consumption of a high-fat/high-sucrose (HF/HS) diet produces hyperglycaemia and hypercholesterolaemia, increases oxidative stress, increases endotoxaemia, expands adipose tissue (with enlarged adipocytes, enhanced macrophage infiltration and the accumulation of cholesterol and oxysterols), and reduces the median lifespan of obese mice. Despite the persistence of obesity, supplementation with a polyphenol-rich plant extract (PRPE) improves plasma lipid levels and endotoxaemia, prevents macrophage recruitment to adipose tissues, reduces adipose accumulation of cholesterol and cholesterol oxides, and extends the median lifespan. PRPE drives the normalization of the HF/HS-mediated functional enrichment of genes associated with immunity and inflammation (in particular the response to lipopolysaccharides). The long-term limitation of immune cell infiltration in adipose tissue by PRPE increases the lifespan through a mechanism independent of body weight and fat storage and constitutes the hallmark of a healthy adiposity trait.
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Registered trials
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