Evidence map›Paper›PMID 31235808›Full record

SynthesisNature communications2019

Genome-wide analysis of dental caries and periodontitis combining clinical and self-reported data.

Dmitry Shungin, Simon Haworth, Kimon Divaris, Cary S Agler, Yoichiro Kamatani, Myoung Keun Lee, Kelsey Grinde, George Hindy, Viivi Alaraudanjoki, Paula Pesonen and 28 more

Registry-linked trialOpen access · goldAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03437798 (Exploring Genomic Determinants of Periodontal Disease Via Shared Genetic Pathways With Cardiovascular Disease, Diabetes, and Bone Density), which is not on this map. Cited by 204 papers, 15 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
204citing papers in PubMed, 15 pooled it
20.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03437798 completednot on this map

Exploring Genomic Determinants of Periodontal Disease Via Shared Genetic Pathways With Cardiovascular Disease, Diabetes, and Bone Density

TypeobservationalSponsorTufts UniversityRan2018 to 2023Enrolled81ConditionsPeriodontal Diseases, Diabetes, Osteoporosis, Cardiovascular Risk FactorArmsDisease status
3 · Its place in the literature

Who cites it

204 citing papers in PubMed, 15 syntheses or guidelines pooled it, 395 citations in OpenAlex.

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144 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

38 authors at 20 institutions in 6 countries.

Dmitry ShunginDepartment of Odontology, Umeå University, Umeå, SE-901 85, Sweden.
Simon HaworthMedical Research Council Integrative Epidemiology Unit, Bristol Medical School, Bristol, BS8 2BN, UK. simon.haworth@bristol.ac.uk.ORCID http://orcid.org/0000-0001-7793-7326
Kimon DivarisDepartment of Pediatric Dentistry, School of Dentistry, University of North Carolina, Chapel Hill, NC, 27599, USA.ORCID http://orcid.org/0000-0003-1290-7251
Cary S AglerDepartment of Oral and Craniofacial Health Sciences, University of North Carolina, Chapel Hill, NC, 27599, USA.
Yoichiro KamataniRIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa, 230-0045, Japan.ORCID http://orcid.org/0000-0001-8748-5597
Myoung Keun LeeCenter for Craniofacial and Dental Genetics, School of Dental Medicine, University of Pittsburgh, Pittsburgh, PA, 15219, USA.
Kelsey GrindeDepartment of Biostatistics, University of Washington, Seattle, WA, 98195, USA.
George HindyLund University, Lund, SE-223 62, Sweden.
Viivi AlaraudanjokiResearch Unit of Oral Health Sciences University of Oulu, Oulu, FI-90014, Finland.
Paula PesonenInfrastructure for Population Studies, Faculty of Medicine, University of Oulu, Oulu, FI-90014, Finland.
Alexander TeumerInstitute for Community Medicine, University Medicine Greifswald, Greifswald, 17475, Germany.ORCID http://orcid.org/0000-0002-8309-094X
Birte HoltfreterDepartment of Restorative Dentistry, Periodontology, Endodontology, and Preventive and Pediatric Dentistry University Medicine Greifswald, Greifswald, 17475, Germany.
Saori SakaueDepartment of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Osaka, 565-0871, Japan.ORCID http://orcid.org/0000-0003-3618-9717
Jun HirataDepartment of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Osaka, 565-0871, Japan.
Yau-Hua YuDivision of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, 02215, USA.ORCID http://orcid.org/0000-0002-4723-5064
Paul M RidkerDivision of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, 02215, USA.
Franco GiulianiniDivision of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, 02215, USA.
Daniel I ChasmanDivision of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, 02215, USA.
Patrik K E MagnussonDepartment of Medical Epidemiology and Biostatistics, Karolinska Instituet, Stockholm, SE-171 77, Sweden.ORCID http://orcid.org/0000-0002-7315-7899
Takeaki SudoDepartment of Periodontology, Graduate School of Medical and Dental Science of Tokyo Medical and Dental University, Tokyo, 113-8510, Japan.
Yukinori OkadaDepartment of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Osaka, 565-0871, Japan.ORCID http://orcid.org/0000-0002-0311-8472
Uwe VölkerDepartment of Functional Genomics, Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, 17475, Germany.ORCID http://orcid.org/0000-0002-5689-3448
Thomas KocherDepartment of Restorative Dentistry, Periodontology, Endodontology, and Preventive and Pediatric Dentistry University Medicine Greifswald, Greifswald, 17475, Germany.ORCID http://orcid.org/0000-0001-9605-2822
Vuokko AnttonenResearch Unit of Oral Health Sciences University of Oulu, Oulu, FI-90014, Finland.
Marja-Liisa LaitalaResearch Unit of Oral Health Sciences University of Oulu, Oulu, FI-90014, Finland.ORCID http://orcid.org/0000-0001-7323-9862
Marju Orho-MelanderLund University, Lund, SE-223 62, Sweden.
Tamar SoferHarvard Medical School, Boston, MA, 02115, USA.ORCID http://orcid.org/0000-0001-8520-8860
John R ShafferCenter for Craniofacial and Dental Genetics, School of Dental Medicine, University of Pittsburgh, Pittsburgh, PA, 15219, USA.ORCID http://orcid.org/0000-0003-1897-1131
Alexandre VieiraDepartment of Oral Biology, University of Pittsburgh, Pittsburgh, PA, 15213, USA.
Mary L MarazitaCenter for Craniofacial and Dental Genetics, School of Dental Medicine, University of Pittsburgh, Pittsburgh, PA, 15219, USA.
Michiaki KuboRIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa, 230-0045, Japan.
Yasushi FuruichiDepartment of Oral Rehabilitation, Division of Periodontology and Endodontology, School of Dentistry, Health Sciences University of Hokkaido, Tobetsu, Hokkaido, 061-0293, Japan.
Kari E NorthDepartment of Epidemiology, University of North Carolina, Chapel Hill, NC 27516, USA.
Steve OffenbacherDepartment of Periodontology, University of North Carolina, Chapel Hill, NC, 27599, USA.
Erik IngelssonDepartment of Medicine, Stanford University School of Medicine, Stanford, CA, 94305, USA.
Paul W FranksDepartment of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University, Malmö, SE-214 28, Sweden.
Nicholas J TimpsonMedical Research Council Integrative Epidemiology Unit, Bristol Medical School, Bristol, BS8 2BN, UK.ORCID http://orcid.org/0000-0002-7141-9189
Ingegerd JohanssonDepartment of Odontology, Umeå University, Umeå, SE-901 85, Sweden.
Brigham and Women's Hospital · USUniversitätsmedizin Greifswald · DEUniversity of North Carolina at Chapel Hill · USUniversity of Pittsburgh · USThe University of Osaka · JPUniversity of Oulu · FILund University · SERIKEN Center for Integrative Medical Sciences · JPBroad Institute · USCardiovascular Institute of the South · USHarvard University · USHealth Sciences University of Hokkaido · JPKarolinska Institutet · SEMRC Integrative Epidemiology UnitOulu University Hospital · FITokyo Medical and Dental University · JPTufts University · USUmeå University · SEUniversity Of Bristol Dental Hospital · GBUniversity of Washington · US

Funding

Psychosocial Influences on Rural Children's Oral HealthR01DE014899 · NIDCR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI FOXMAN, BETSY, MARAZITA, MARY L. · 2002 to 2020
$39.9M
Stanford Islet Research CoreP30DK116074 · NIDDK · STANFORD UNIVERSITY · PI Seung K Kim · 2017 to 2026
$19.5M
Genome-Wide Association Study of Early Childhood CariesU01DE025046 · NIDCR · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DIVARIS, KIMON · 2015 to 2019
$8.4M
Dental Caries: Whole Genome Association and Gene x Environment StudiesU01DE018903 · NIDCR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MARAZITA, MARY L. · 2007 to 2010
$1.2M
Exploring genomic determinants of periodontal disease via shared genetic pathways with cardiovascular disease, diabetes, and bone densityK23DE026804 · NIDCR · TUFTS UNIVERSITY BOSTON · PI YU, YAU-HUA · 2017 to 2021
$685k
Cancer Research UK (CRUK) C18281/A19169Medical Research Council G9815508Medical Research Council MC_PC_15018NIDCR NIH HHS K23 DE026804NIDCR NIH HHS L30 DE028110NIDCR NIH HHS R01 DE014899NIDCR NIH HHS U01 DE018903NIDCR NIH HHS U01 DE025046NIDDK NIH HHS P30 DK116074Vetenskapsrådet (Swedish Research Council) 2015-02597Vetenskapsrådet (Swedish Research Council) 4.1-2016-00416Vetenskapsrådet (Swedish Research Council) Dnr 2011-3372Wellcome Trust 202802/Z/16/Z
6 · The paper itself

Abstract

Dental caries and periodontitis account for a vast burden of morbidity and healthcare spending, yet their genetic basis remains largely uncharacterized. Here, we identify self-reported dental disease proxies which have similar underlying genetic contributions to clinical disease measures and then combine these in a genome-wide association study meta-analysis, identifying 47 novel and conditionally-independent risk loci for dental caries. We show that the heritability of dental caries is enriched for conserved genomic regions and partially overlapping with a range of complex traits including smoking, education, personality traits and metabolic measures. Using cardio-metabolic traits as an example in Mendelian randomization analysis, we estimate causal relationships and provide evidence suggesting that the processes contributing to dental caries may have undesirable downstream effects on health.

Indexed as

Genetic Predisposition to DiseaseGenome-Wide Association StudyDental CariesGenomicsHeredityHumansMendelian Randomization AnalysisPeriodontitisPolymorphism, Single NucleotideQuantitative Trait LociSelf Report

Identifiers

PMID31235808
PMCPMC6591304
OpenAlexW2945665018

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.