Evidence map›Paper›PMID 31235807›Full record

ArticleNature communications2019

Chromosome dynamics near the sol-gel phase transition dictate the timing of remote genomic interactions.

Nimish Khanna, Yaojun Zhang, Joseph S Lucas, Olga K Dudko, Cornelis Murre

Abstract read
In one paragraph

Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 77 papers.

0numbers the graph read from it
0cells of the map it votes in
77citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

77 citing papers in PubMed.

  1. Active processes shape and move the genome and nucleoplasm.Current opinion in genetics & development · 2026
    Review
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  17. Phase Separation in Chromatin Organization and Human Diseases.International journal of molecular sciences · 2025
    Review
  18. Review
  19. Article
  20. Helical coiled nucleosome chromosome architectures during cell cycle progression.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article

17 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Nimish KhannaDivision of Biological Sciences, 0377, Department of Molecular Biology, University of California, San Diego, La Jolla, CA, 92093, USA.
Yaojun ZhangPrinceton Center for Theoretical Science, Princeton University, Princeton, NJ, 08544, USA.
Joseph S LucasDivision of Biological Sciences, 0377, Department of Molecular Biology, University of California, San Diego, La Jolla, CA, 92093, USA.
Olga K DudkoDepartment of Physics, University of California, San Diego, La Jolla, CA, 92093, USA. dudko@physics.ucsd.edu.
Cornelis MurreDivision of Biological Sciences, 0377, Department of Molecular Biology, University of California, San Diego, La Jolla, CA, 92093, USA. murre@biomail.ucsd.edu.

Funding

San Diego Center for 4D Nucleome ResearchU54DK107977 · NIDDK · LUDWIG INSTITUTE FOR CANCER RES LTD · PI MURRE, CORNELIS, REN, BING · 2015 to 2019
$9.4M
U of Calif, San Diego Neuroscience Microscopy ImagingP30NS047101 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GLEESON, JOSEPH G, ZHENG, BINHAI · 2003 to 2022
$9.0M
The 3D-Structures of the Immunoglobulin Heavy Chain LocusR01AI082850 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MURRE, CORNELIS · 2009 to 2024
$5.4M
Recognition Of The Dendritic Cell Surface Receptor Dc-sign By HIV Gp120Z01AI000880 · NIAID · NIAID EXTRAMURAL ACTIVITIES · PI SUN, PETER D. · 2001 to 2008
$959k
Intramural NIH HHS Z01 AI000880NIAID NIH HHS R01 AI082850NIDDK NIH HHS U54 DK107977NINDS NIH HHS P30 NS047101U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (NIAID) U54DK24230, AI082850, AI00880
6 · The paper itself

Abstract

Diverse antibody repertoires are generated through remote genomic interactions involving immunoglobulin variable (V

Indexed as

AnimalsB-LymphocytesCell LineChromatinChromosomesDNA-Binding ProteinsGene Expression RegulationGenes, ImmunoglobulinGenomicsImmunoglobulin Heavy ChainsImmunoglobulin Variable RegionMicePhase TransitionV(D)J RecombinationChromatinDNA-Binding ProteinsImmunoglobulin Heavy ChainsImmunoglobulin Variable RegionRag2 protein, mouse

Identifiers

PMID31235807
PMCPMC6591236

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.