ReviewNature reviews. Endocrinology2019
Sperm RNA code programmes the metabolic health of offspring.
Review in Nature reviews. Endocrinology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06147700 (Identifying Molecular Determinants of Infertility in Men), which is not on this map. Cited by 138 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Identifying Molecular Determinants of Infertility in Men (MODIFY)
Who cites it
138 citing papers in PubMed.
- Combined effects of urine exposure and cryopreservation on sperm quality: an in vitro study of retrograde ejaculation.Asian journal of andrology · 2026Article
- Transfer RNA-derived small RNAs: from biogenesis to regulatory roles in male reproductive system.Journal of human genetics · 2026Review
- ExposoGenomics: integrating genome and exposome as jointly dynamic systems for causal discovery and precision health.Human genomics · 2026Review
- Paternal Circadian Disruption Impairs Offspring Cognition via Sperm microRNAs.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- PANDORA-seq reveals human sperm sncRNA signature endowed with sperm quality assessment.Genes & diseases · 2026Article
- Deciphering RNA modification dynamics during spermatogenesis and sperm maturation.Science China. Life sciences · 2026Article
- High-sensitivity in situ detection of Sox21 reveals transcript asymmetry from the zygote stage.Developmental biology · 2026Article
- Male obesity causes adipose mitochondrial dysfunction in FNature communications · 2026Article
- Conserved shifts in sperm small non-coding RNA profiles during mouse and human aging.The EMBO journal · 2026Article
- Paternal Microplastic Exposure Alters Sperm Small Noncoding RNAs and Affects Offspring Metabolic Health in Mice.Journal of the Endocrine Society · 2026Article
- Paternal immune activation-induced alteration of 28S rRNA-derived small RNAs in sperm reprograms offspring phenotypes.PNAS nexus · 2026Article
- Extracellular Vesicles, Nutrient Balance, and Redox Metabolism During Epididymal Sperm Maturation: A Perspective on the Complexity of Intercellular Interplay.Advances in anatomy, embryology, and cell biology · 2026Review
- Amyloid-mediated RNA uptake by sperm for embryonic delivery.bioRxiv : the preprint server for biology · 2025Article
- Ignoring the planet: A critical blind spot for research on ageing.Journal of internal medicine · 2025Review
- Impact of physical activity on semen quality: a review of current evidence.Asian journal of andrology · 2025Review
- Transfer RNA-derived small RNAs (tsRNAs): A rising star in liquid biopsy.Genes & diseases · 2025Review
- Review
- Queuosine is incorporated into precursor tRNA before splicing.Nature communications · 2025Article
- Episodic Exposure to Eucalyptus Smoke during Sperm Maturation Impairs Sperm Motility in Long Evans Rats.Environmental science & technology · 2025Article
- Copy number determination of sperm-borne small RNAs implied in the intergenerational inheritance of metabolic syndromes.RNA (New York, N.Y.) · 2025Article
78 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Mammalian sperm RNA is increasingly recognized as an additional source of paternal hereditary information beyond DNA. Environmental inputs, including an unhealthy diet, mental stresses and toxin exposure, can reshape the sperm RNA signature and induce offspring phenotypes that relate to paternal environmental stressors. Our understanding of the categories of sperm RNAs (such as tRNA-derived small RNAs, microRNAs, ribosomal RNA-derived small RNAs and long non-coding RNAs) and associated RNA modifications is expanding and has begun to reveal the functional diversity and information capacity of these molecules. However, the coding mechanism endowed by sperm RNA structures and by RNA interactions with DNA and other epigenetic factors remains unknown. How sperm RNA-encoded information is decoded in early embryos to control offspring phenotypes also remains unclear. Complete deciphering of the 'sperm RNA code' with regard to metabolic control could move the field towards translational applications and precision medicine, and this may lead to prevention of intergenerational transmission of obesity and type 2 diabetes mellitus susceptibility.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.