Evidence map›Paper›PMID 31235782›Full record

ArticleJournal of perinatology : official journal of the California Perinatal Association2019

Multi-component lipid emulsion vs soy-based lipid emulsion for very low birth weight preterm neonates: A pre-post comparative study.

Ranjit Torgalkar, Shruti Dave, Jyotsna Shah, Nastaran Ostad, Kirsten Kotsopoulos, Sharon Unger, Prakesh S Shah

Abstract readComparative Study
PubMed Publisher
In one paragraph

Article in Journal of perinatology : official journal of the California Perinatal Association, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 2 pooled it
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 41 citations in OpenAlex.

  1. Pooled it
  2. New-generation intravenous fat emulsions and bronchopulmonary dysplasia in preterm infants: a systematic review and meta-analysis.Journal of perinatology : official journal of the California Perinatal Association · 2020
    Pooled it
  3. Trial
  4. Article
  5. Article
  6. Article
  7. Article
  8. Effects of Fish Oil (SMOFlipidMedeniyet medical journal · 2022
    Article
  9. Parenteral lipid emulsions in the preterm infant: current issues and controversies.Archives of disease in childhood. Fetal and neonatal edition · 2021
    Review
  10. [Clinical effect of multi-oil fat emulsion for parenteral nutrition support in extremely low birth weight infants].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2021
    Article
  11. Review
  12. Biochemical Parameters in Extremely Preterm Infants Receiving Mixed Lipid Emulsions.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG · 2021
    Article
  13. Article
  14. Is SMOF lipid emulsion better than soy-based lipid emulsion for low birth weight preterm neonates?Journal of perinatology : official journal of the California Perinatal Association · 2020
    Article
  15. Article
  16. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Ranjit TorgalkarDepartment of Pediatrics, Mount Sinai Hospital, Toronto, Ontario, Canada.
Shruti DaveDepartment of Pediatrics, Mount Sinai Hospital, Toronto, Ontario, Canada.
Jyotsna ShahDepartment of Pediatrics, Mount Sinai Hospital, Toronto, Ontario, Canada.
Nastaran OstadDepartment of Pediatrics, Mount Sinai Hospital, Toronto, Ontario, Canada.
Kirsten KotsopoulosDepartment of Pediatrics, Mount Sinai Hospital, Toronto, Ontario, Canada.
Sharon UngerDepartment of Pediatrics, Mount Sinai Hospital, Toronto, Ontario, Canada.
Prakesh S ShahDepartment of Pediatrics, Mount Sinai Hospital, Toronto, Ontario, Canada. Prakeshkumar.Shah@sinaihealthsystem.ca.ORCID http://orcid.org/0000-0002-9920-0488
Mount Sinai Hospital · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo examine the effectiveness of soybean oil-medium chain triglycerides-olive oil-fish oil lipid emulsion (SMOF-LE) on clinical outcomes of very-low-birth-weight neonates. STUDY

designWe conducted a pre-post comparative study of very-low-birth-weight neonates, dividing them according to lipid emulsion received: Intralipid (soy-based; n = 680) or SMOF-LE (n = 617). Primary outcomes were mortality, chronic lung disease, severe retinopathy, infection, and necrotising enterocolitis. Secondary outcomes were cholestasis, osteopenia, time to full feeds, and time to regain birthweight.

resultsBaseline characteristics between groups were comparable. Primary outcomes did not differ significantly between groups, although any retinopathy was significantly lower in the SMOF-LE group. SMOF-LE group had lower odds of cholestasis, osteopenia, and lipid interruption, and reduced times to full feeds and to regain birthweight.

conclusionsCompared with Intralipid, SMOF-LE was not associated with differences in mortality and major morbidities but was associated with lower odds of any retinopathy, cholestasis, and osteopenia; and improved lipid tolerance.

Indexed as

Fat Emulsions, IntravenousInfant, PrematureInfant, Very Low Birth WeightPhospholipidsSoybean OilCross InfectionEmulsionsEnterocolitis, NecrotizingFemaleFish OilsHumansInfant, NewbornInfant, Premature, DiseasesMaleParenteral NutritionRetinopathy of PrematurityEmulsionsFat Emulsions, IntravenousFish OilsPhospholipidsSoybean Oilsoybean oil, phospholipid emulsion

Identifiers

PMID31235782
OpenAlexW2950438188

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.