Evidence map›Paper›PMID 31235769›Full record

ArticleScientific reports2019

Characterization of metal binding of bifunctional kinase/phosphatase AceK and implication in activity modulation.

Xiaoying Zhang, Qingya Shen, Zhen Lei, Qianyi Wang, Jimin Zheng, Zongchao Jia

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Evolution-assisted engineering ofBiodesign research · 2025
    Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Xiaoying ZhangCollege of Chemistry, Beijing Normal University, Beijing, 100875, China.
Qingya ShenCollege of Chemistry, Beijing Normal University, Beijing, 100875, China.
Zhen LeiCollege of Chemistry, Beijing Normal University, Beijing, 100875, China.
Qianyi WangCollege of Chemistry, Beijing Normal University, Beijing, 100875, China.
Jimin ZhengCollege of Chemistry, Beijing Normal University, Beijing, 100875, China. jimin_z@bnu.edu.cn.
Zongchao JiaDepartment of Biomedical and Molecular Sciences, Queen's University, Kingston, Ontario, K7L3N6, Canada. jia@queensu.ca.ORCID http://orcid.org/0000-0002-9322-9394

Funding

CIHR
6 · The paper itself

Abstract

A unique bifunctional enzyme, isocitrate dehydrogenase kinase/phosphatase (AceK) regulates isocitrate dehydrogenase (IDH) by phosphorylation and dephosphorylation in response to nutrient availability. Herein we report the crystal structure of AceK in complex with ADP and Mn

Indexed as

Adenosine DiphosphateCatalytic DomainEscherichia coliEscherichia coli ProteinsIsocitrate DehydrogenaseKineticsMagnesiumManganeseModels, MolecularMutationProtein BindingAceK protein, E coliAdenosine DiphosphateEscherichia coli ProteinsIsocitrate DehydrogenaseMagnesiumManganese

Identifiers

PMID31235769
PMCPMC6591243

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.