ArticleScientific reports2019
A model of ganglion axon pathways accounts for percepts elicited by retinal implants.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers, 1 of them a synthesis that pooled it.
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Who cites it
71 citing papers in PubMed, 1 synthesis or guideline pooled it, 148 citations in OpenAlex.
- A systematic review of extended reality (XR) for understanding and augmenting vision loss.Journal of vision · 2023Pooled it
- Evaluating the Efficacy of Smart Saliency Detection System for Visual Prosthesis Users: An Experimental Comparison Across Various Visual Prosthesis Implants.Artificial organs · 2026Article
- Crosstalk-free optical indicator-actuator combinations for bidirectional optogenetics.npj biomedical innovations · 2026Review
- Modalities of vision restoration in optic neuropathies and retinal disease.Progress in retinal and eye research · 2026Review
- Maximizing the fidelity of a photovoltaic subretinal prosthesis for human patients.Journal of neural engineering · 2026Article
- Gamification Enhances User Engagement and Task Performance in Prosthetic Vision Testing.Translational vision science & technology · 2026Article
- Fuzzing the brain: automated stress testing for the safety of ML-driven neurostimulation.Journal of neural engineering · 2026Article
- Gamification Enhances User Engagement and Task Performance in Prosthetic Vision Testing.medRxiv : the preprint server for health sciences · 2025Article
- Visual-tactile shape perception in Argus II Participants: The impact of prolonged device use and blindness on performance.Journal of vision · 2025Article
- Optimizing electrical stimulation parameters to enhance visual cortex activation in retina degeneration rats.Scientific reports · 2025Article
- Simulated prosthetic vision confirms checkerboard as an effective raster pattern for epiretinal implants.Journal of neural engineering · 2025Article
- Evaluating Deep Human-in-the-Loop Optimization for Retinal Implants Using Sighted Participants.Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference · 2025Article
- Efficient Spatial Estimation of Perceptual Thresholds for Retinal Implants via Gaussian Process Regression.Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference · 2025Article
- Visual cortical thickness increases with prolonged artificial vision restoration.Cerebral cortex (New York, N.Y. : 1991) · 2025Article
- Machine Learning Techniques for Simulating Human Psychophysical Testing of Low-Resolution Phosphene Face Images in Artificial Vision.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Visual Prostheses in the Era of Artificial Intelligence Technology.Eye and brain · 2025Review
- Static or Temporal? Semantic Scene Simplification to Aid Wayfinding in Immersive Simulations of Bionic Vision.Proceedings of the ACM Symposium on Virtual Reality Software and Technology. ACM Symposium on Virtual Reality Software and Technology · 2025Article
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- Spatially Localized Visual Perception Estimation by Means of Prosthetic Vision Simulation.Journal of imaging · 2024Article
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11 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Degenerative retinal diseases such as retinitis pigmentosa and macular degeneration cause irreversible vision loss in more than 10 million people worldwide. Retinal prostheses, now implanted in over 250 patients worldwide, electrically stimulate surviving cells in order to evoke neuronal responses that are interpreted by the brain as visual percepts ('phosphenes'). However, instead of seeing focal spots of light, current implant users perceive highly distorted phosphenes that vary in shape both across subjects and electrodes. We characterized these distortions by asking users of the Argus retinal prosthesis system (Second Sight Medical Products Inc.) to draw electrically elicited percepts on a touchscreen. Using ophthalmic fundus imaging and computational modeling, we show that elicited percepts can be accurately predicted by the topographic organization of optic nerve fiber bundles in each subject's retina, successfully replicating visual percepts ranging from 'blobs' to oriented 'streaks' and 'wedges' depending on the retinal location of the stimulating electrode. This provides the first evidence that activation of passing axon fibers accounts for the rich repertoire of phosphene shape commonly reported in psychophysical experiments, which can severely distort the quality of the generated visual experience. Overall our findings argue for more detailed modeling of biological detail across neural engineering applications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.