ArticleScientific reports2019
Identifying pre-disease signals before metabolic syndrome in mice by dynamical network biomarkers.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed.
- Marine MicroalgaMarine drugs · 2026Article
- Detection of pre-transition phases during biological development using single-sample network entropy (SNE).NPJ systems biology and applications · 2025Article
- Altered Hippocampal Transcriptomic Profile Reveals Cognitive Impairment in Young Metabolically Obese, Normal-Weight Rats, Prevented by Perinatal Leptin Intake.Molecular nutrition & food research · 2025Article
- Dynamical network markers for heterogeneous hierarchical networks.Scientific reports · 2025Article
- "Weibing" in traditional Chinese medicine-biological basis and mathematical representation of disease-susceptible state.Acta pharmaceutica Sinica. B · 2025Review
- Article
- Olfactory bulbectomy-induced impairment of lipid utilization leads to abnormal glucose metabolism in mice.PloS one · 2025Article
- Moderating effects of a healthy lifestyle on the association of pre-metabolic syndrome with multiple chronic disease comorbidities.Frontiers in public health · 2025Article
- Energy landscape analysis of health checkup data clarified multiple pathways to diabetes development in obese and non-obese subjects.Frontiers in endocrinology · 2025Observational
- Risk factors for metabolic syndrome in the premetabolic state assessed using hierarchical clustering study in a health screening group.Scientific reports · 2024Article
- Time-dependent changes in genome-wide gene expression and post-transcriptional regulation across the post-death process in silkworm.DNA research : an international journal for rapid publication of reports on genes and genomes · 2024Article
- Anticipating regime shifts by mixing early warning signals from different nodes.Nature communications · 2024Article
- Establishing Monoclonal Gammopathy of Undetermined Significance as an Independent Pre-Disease State of Multiple Myeloma Using Raman Spectroscopy, Dynamical Network Biomarker Theory, and Energy Landscape Analysis.International journal of molecular sciences · 2024Article
- Yuragi biomarker concept for evaluating human induced pluripotent stem cells using heterogeneity-based Raman finger-printing.Biophysics and physicobiology · 2024Article
- Appropriate sleep duration modifying the association of insulin resistance and hepatic steatosis is varied in different status of metabolic disturbances among adults from the United States, NHANES 2017-March 2020.Preventive medicine reports · 2023Article
- Trehalose metabolism coordinates transcriptional regulatory control and metabolic requirements to trigger the onset of cassava storage root initiation.Scientific reports · 2023Article
- Review
- Practices, Potential, and Perspectives for Detecting Predisease Using Raman Spectroscopy.International journal of molecular sciences · 2023Review
- Phytochemicals and Vitamin D for a Healthy Life and Prevention of Diseases.International journal of molecular sciences · 2023Review
- Article
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Authors and funding
11 authors.
Funding
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Abstract
The establishment of new therapeutic strategies for metabolic syndrome is urgently needed because metabolic syndrome, which is characterized by several disorders, such as hypertension, increases the risk of lifestyle-related diseases. One approach is to focus on the pre-disease state, a state with high susceptibility before the disease onset, which is considered as the best period for preventive treatment. In order to detect the pre-disease state, we recently proposed mathematical theory called the dynamical network biomarker (DNB) theory based on the critical transition paradigm. Here, we investigated time-course gene expression profiles of a mouse model of metabolic syndrome using 64 whole-genome microarrays based on the DNB theory, and showed the detection of a pre-disease state before metabolic syndrome defined by characteristic behavior of 147 DNB genes. The results of our study demonstrating the existence of a notable pre-disease state before metabolic syndrome may help to design novel and effective therapeutic strategies for preventing metabolic syndrome, enabling just-in-time preemptive interventions.
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